How MLK3 affects cell adhesion in cancer cells
Official title: Regulation of Cadherins by MLK3
Funded at University of Toledo · NIH-10793060 · Data updated 2026-11-12
This study is looking at how a protein called MLK3 affects how ovarian and breast cancer cells stick together and move around, which could help us understand how cancer spreads and find new ways to treat it.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $451,500 |
| NIH project number | 1R15GM152942-01 |
| Project ID | NIH-10793060 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with ovarian or breast cancer, particularly those with epithelial tumors.
✕Less likely to help
Patients with non-epithelial cancers or those not diagnosed with ovarian or breast cancer may not benefit from this research.
What this research studies
This research investigates the role of a protein called MLK3 in regulating cell adhesion in ovarian and breast cancer cells. By using techniques like siRNA knockdown, the researchers aim to understand how MLK3 influences the behavior of these cells, particularly in their ability to stick together and migrate. The study focuses on the relationship between MLK3 and important proteins involved in cell junctions, such as E-cadherin and N-cadherin, which are crucial for maintaining tissue structure and function. Patients may benefit from insights gained about how cancer cells spread and how to potentially target these processes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cancer cell migration and invasion, improving treatment outcomes for patients.
How similar studies have gone: Other research has shown promising results in understanding the role of cell adhesion proteins in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Toledo
Toledo, United States Active
Researchers
- Principal investigator: Chadee, Deborah N — University of Toledo
- Study coordinator: Chadee, Deborah N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.