Understanding how a specific protein affects cell junctions in epithelial tissues
Regulation of epithelial junctions stability and turnover by the RhoG exchange factor SGEF
['FUNDING_R15'] · UNIVERSITY OF TOLEDO · NIH-10974904
This study is looking at how a protein called SGEF helps keep the connections between cells strong and stable, which is important for the health of tissues in our body, and it could help us understand more about conditions that affect these connections.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TOLEDO (nih funded) |
| Locations | 1 site (TOLEDO, UNITED STATES) |
| Trial ID | NIH-10974904 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called SGEF in maintaining the stability and turnover of cell junctions in epithelial cells. Epithelial cells are crucial for forming barriers in the body, and this study aims to uncover how SGEF interacts with other proteins to regulate these junctions. By using advanced techniques, the researchers will explore the molecular mechanisms behind cell adhesion and polarity, which are vital for proper tissue function. The findings could lead to better understanding of various conditions related to cell adhesion and tissue integrity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to epithelial cell dysfunction, including certain types of cancer or congenital abnormalities.
Not a fit: Patients with conditions unrelated to epithelial cell adhesion or stability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treating conditions related to epithelial dysfunction, such as certain cancers and birth defects.
How similar studies have performed: Other research has shown success in understanding cell junctions and their regulation, making this approach promising but still focused on a specific protein interaction.
Where this research is happening
TOLEDO, UNITED STATES
- UNIVERSITY OF TOLEDO — TOLEDO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GARCIA-MATA, RAFAEL — UNIVERSITY OF TOLEDO
- Study coordinator: GARCIA-MATA, RAFAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers