Identifying and studying toxic compounds from harmful algae blooms
Official title: Discovery of Novel Cyanotoxins by Detection of Their Native Fluorescence and Unique MS/MS Fragments, and Determination of Their Toxicities
Funded at University of Toledo · NIH-10974926 · Data updated 2026-11-12
This study is looking at harmful substances made by blue-green algae in Lake Erie to see how they affect liver and kidney cells, helping us find better ways to keep our water safe during these algae blooms.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | August 16, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $459,353 |
| NIH project number | 1R15ES036709-01 |
| Project ID | NIH-10974926 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who may be exposed to contaminated water from harmful algal blooms, particularly those living near affected water bodies.
✕Less likely to help
Patients who are not exposed to water sources affected by harmful algal blooms may not benefit from this research.
What this research studies
This research focuses on discovering and analyzing toxic compounds produced by harmful cyanobacterial blooms, which can contaminate water sources. By using advanced techniques like fluorescence detection and mass spectrometry, the researchers aim to identify and purify various cyanopeptides that are difficult to detect. The study will involve analyzing samples from Lake Erie to understand the toxic effects of these compounds on liver and kidney cells. This approach could lead to better understanding and management of water safety during harmful algal blooms.
Why it matters
Potential benefit: If successful, this research could improve water safety and public health by identifying harmful toxins in water sources.
How similar studies have gone: Previous research has shown success in identifying toxins from harmful algal blooms using similar detection methods, indicating a promising approach.
Where this research is happening
-
University of Toledo
Toledo, United States Active
Researchers
- Principal investigator: Isailovic, Dragan — University of Toledo
- Study coordinator: Isailovic, Dragan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.