Centrosomal JAK2 in ciliated cells impacts ciliogenesis and cell behavior
Official title: Centrosomal JAK2 in ciliated cells
Funded at University of Toledo · NIH-11443649 · Data updated 2026-11-12
A research grant aims to understand how JAK2 at the centrosome affects ciliogenesis and related cell functions in conditions like Alzheimer’s disease.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $573,750 |
| NIH project number | 1R15GM166766-01 |
| Project ID | NIH-11443649 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with conditions related to ciliopathies or neurodegenerative diseases where centrosome and JAK2 signaling pathways may play a role, or researchers who can contribute patient-derived cell models.
✕Less likely to help
Individuals without ciliopathy- or neurodegenerative disease-relevant biology may not directly benefit from this basic mechanistic study.
What this research studies
This project seeks to map how JAK2, a signaling protein, stays at the centrosome in cells with cilia and how that location affects cilia formation and key cell activities such as growth and movement. Using cellular and molecular methods, the team will identify parts of JAK2 that direct it to the centrosome and study how this localization changes signaling pathways relevant to disease. The work could reveal new links between centrosome biology, ciliopathies, and cancers that may influence future therapies. The study is performed in human-relevant cell systems to better understand disease-associated processes.
Why it matters
Potential benefit: Could lead to new targets for therapies addressing ciliopathy- and cancer-related pathways.
How similar studies have gone: Similar work has shown that centrosomal localization of signaling proteins can modulate cell functions, but the specific role of cent-JAK2 in ciliogenesis is still being explored.
Where this research is happening
-
University of Toledo
Toledo, United States Active
Researchers
- Principal investigator: Diakonova, Maria — University of Toledo
- Study coordinator: Diakonova, Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.