Investigating how certain proteins influence the development of blood cells.
Official title: The Erk1/2-c-Fos/Egr1 Pathway in Neutrophil versus Monocyte Lineage Specification
Funded at University of Toledo · NIH-10113925 · Data updated 2026-11-12
This study is looking at how certain proteins help shape the development of important blood cells, like neutrophils and monocytes, which could lead to better ways to treat infections and blood disorders for patients.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2021 |
| Award (this year) | $451,500 |
| NIH project number | 1R15HL156109-01 |
| Project ID | NIH-10113925 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to bacterial infections or blood cell disorders.
✕Less likely to help
Patients with unrelated health conditions or those not affected by blood cell development issues may not receive any benefit from this research.
What this research studies
This research focuses on understanding how specific proteins and signaling pathways affect the development of different types of blood cells, particularly neutrophils and monocytes. By examining the roles of cytokines and transcription factors, the study aims to uncover the mechanisms that guide cell fate decisions in the hematopoietic system. Patients may benefit from insights gained about how to better manage or treat conditions related to bacterial infections and blood cell disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bacterial infections and blood-related diseases by enhancing our understanding of blood cell development.
How similar studies have gone: Previous research has shown promising results in understanding blood cell development through similar signaling pathway investigations.
Where this research is happening
-
University of Toledo
Toledo, United States Active
Researchers
- Principal investigator: Dong, Fan — University of Toledo
- Study coordinator: Dong, Fan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.