Understanding how polycystins control cell size during growth
Official title: The mechanism of cell size regulation by polycystins
Funded at University of Toledo · NIH-11061294 · Data updated 2026-11-12
This study is looking at how certain proteins called polycystins help control cell size during growth, using fission yeast as a model, to better understand the processes that might be involved in conditions like Autosomal Dominant Polycystic Kidney Disease (ADPKD).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project start | April 15, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $277,630 |
| NIH project number | 5R01GM144652-04 |
| Project ID | NIH-11061294 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease (ADPKD).
✕Less likely to help
Patients with other forms of kidney disease unrelated to polycystin function may not benefit from this research.
What this research studies
This research investigates the role of polycystins, specifically the Pkd2p channel, in regulating cell size during the growth phase of cell division. By studying the model organism fission yeast, the researchers aim to uncover how calcium signaling and specific pathways influence the transition from cell division to growth. The study will utilize genetic screening and calcium imaging techniques to explore the interactions between polycystins and signaling pathways that affect cell size. This could provide insights into the cellular mechanisms underlying conditions like Autosomal Dominant Polycystic Kidney Disease (ADPKD).
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing ADPKD and improving patient outcomes.
How similar studies have gone: While the specific mechanisms of polycystins are still being explored, previous research has shown promising results in understanding calcium signaling in cell growth, indicating potential for success in this area.
Where this research is happening
-
University of Toledo
Toledo, United States Active
Researchers
- Principal investigator: Chen, Qian — University of Toledo
- Study coordinator: Chen, Qian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.