Investigating how a specific gene affects cell division and cancer development
MTFR2 in the control of mitochondrial dynamics and mitotic spindle integrity
This study is looking at how a specific gene called MTFR2 affects the way cancer cells divide and how problems with cell energy can lead to mistakes in their genetic material, which could help us find new ways to treat cancer.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Toledo NIH-funded |
| Lab location | 1 site (Toledo, United States) |
| Project ID | NIH-10514925 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the MTFR2 gene in regulating mitochondrial dynamics and its impact on cell division, particularly in cancer cells. The study aims to explore how defects in mitochondrial function can lead to errors in chromosome segregation during mitosis, which is crucial for maintaining genetic stability. By using advanced techniques like CRISPR to manipulate the MTFR2 gene, researchers will analyze its effects on cell behavior and cancer progression. Patients may benefit from insights gained about cancer cell behavior and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers that exhibit chromosomal instability.
Not a fit: Patients with non-cancerous conditions or those whose cancers do not involve mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers by targeting the mechanisms of cell division.
How similar studies have performed: Previous research has shown that targeting mitochondrial dynamics can influence cancer cell behavior, suggesting a promising avenue for further exploration.
Where this research is happening
Toledo, United States
- University of Toledo — Toledo, United States (Active)
Researchers
- Principal investigator: Liu, Song-Tao — University of Toledo
- Study coordinator: Liu, Song-Tao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.