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Clinical trials and research at University of South Florida

• 39Clinical trials
• 323NIH research projects
• 1New in 30 days
• 6Countries

Newest trials

All recruiting trials (39)

• Hangeoreum: a self-paced web program to reduce loneliness for Korean immigrants aged 50 and older

  A self-guided, web-based program based on ACT is being tested to see if it helps Korean immigrants 50+ feel less lonely and more connected.

  Recruiting University of South Florida · Tampa, Florida · NCT07917013

• Gut and Oral Microbiome and Cognitive Health in Aging

  This study tests whether differences in gut and mouth bacteria are linked to cognitive health in adults across ages and cognitive status.

  Recruiting University of South Florida · Tampa, Florida · NCT07799402

• LpD3.5 Intervention for Gut Health and Cognition in Older Adults with MCI

  In older adults with mild cognitive impairment, this study tests whether daily LpD3.5 capsules can improve gut health and potentially cognition compared with placebo.

  Recruiting Early Phase 1 University of South Florida · Tampa, Florida · NCT07794956

• Spatial Cues, Task Demands, and Auditory Attention in Hearing Loss and Cochlear Implants

  This study tests how spatial hearing cues and task demands affect listening and attention in people with normal hearing and those with bilateral cochlear implants.

  Recruiting University of South Florida · Tampa, Florida · NCT07765186

• Advanced vs Conventional Ankle Foot Orthoses for Lower Limb Injury

  This study tests whether advanced energy-storing AFOs improve comfort and function for adults with lower limb injuries who use AFOs.

  Recruiting at 3 sites University of South Florida · Tampa, Florida and 2 other locations · NCT07721792

• Gepants for Acute Migraine in the Emergency Department

  This study tests whether rimegepant or zavegepant given in the ED can relieve an acute migraine for adults.

  Recruiting Phase 1 University of South Florida · Tampa, Florida · NCT07667621

• Dry needling to help MS-related leg pain and walking

  This study tests whether dry needling can lessen chronic leg pain and improve balance and walking in adults with multiple sclerosis.

  Recruiting University of South Florida · Tampa, Florida · NCT07615725

• Pharmacist-led continuous glucose monitoring for people with prediabetes

  Pharmacists will try continuous glucose monitoring to see if it improves blood sugar and health habits in adults with prediabetes.

  Recruiting at 2 sites University of South Florida · Tampa, Florida and 1 other locations · NCT07529366

• Behavioral parent-training with HOT DOCS and DOCS K-5 for caregivers of children ages 0–12.

  This program tests whether group HOT DOCS and DOCS K-5 parent-training classes can help caregivers of children ages 0–12 reduce common challenging behaviors like tantrums, whining, and noncompliance.

  Recruiting University of South Florida · Tampa, Florida · NCT07505381

• Acoltremon 0.003% eye drops to improve tears and corneal health in Stage 1 neurotrophic keratopathy

  This study will test whether Acoltremon 0.003% eye drops, used twice daily, can increase tear production and improve corneal signs in people with Stage 1 neurotrophic keratopathy who have low tear production.

  Recruiting Phase 4 University of South Florida · Tampa, Florida · NCT07502378

• Moving the uterus, ovaries, and fallopian tubes out of the pelvis before whole pelvic radiation to preserve fertility.

  This trial tries moving the uterus, ovaries, and fallopian tubes out of the pelvis before whole pelvic radiation in women aged 18–40 who want to preserve their ability to have children.

  Recruiting University of South Florida · Tampa, Florida · NCT07419490

• Boosting referrals to asthma specialists after an ER visit

  This study tests whether arranging a telehealth follow-up with an asthma specialist from the ER helps adults with asthma see a specialist within 3 months more often than usual referrals.

  Recruiting University of South Florida · Tampa, Florida · NCT07396987

• ACT Together: web program with brief coaching for parents of children with disabilities in pediatric outpatient clinics

  This project will test a six-module web-based Acceptance and Commitment Therapy program plus brief phone coaching to help parents of children with disabilities manage stress and mood.

  Recruiting University of South Florida · Tampa, Florida · NCT07360600

• Self-affirmation and heart responses during grief

  This trial will test whether a brief self-affirmation exercise helps adults grieving a recent loss have calmer heart and blood pressure responses during and after recalling their loss.

  Recruiting University of South Florida · Tampa, Florida · NCT07356635

• WeACT: a web-based program to help family caregivers of people with dementia

  A self-paced online program called WeACT is being tested to help adult family caregivers of relatives with dementia manage depressive symptoms and improve coping.

  Recruiting University of South Florida · Tampa, Florida · NCT07342569

• Immediate Lymphatic Reconstruction to prevent breast cancer–related lymphedema

  This will test whether doing Immediate Lymphatic Reconstruction during axillary lymph node removal can prevent lymphedema in women at high risk after breast cancer surgery.

  Recruiting at 3 sites University of South Florida · Tampa, Florida and 2 other locations · NCT07127003

• NiteCAPP Jr: a digital CBT sleep program for kids aged 6–12 with insomnia

  This will test whether a digital cognitive behavioral therapy program called NiteCAPP Jr, delivered with caregiver support, can help children aged 6–12 who have insomnia compared with being on a waitlist.

  Recruiting University of South Florida · Tampa, Florida · NCT07091149

• Balloon guide catheter versus conventional guide catheter for clot removal in ischemic stroke

  This study will test whether a balloon guide catheter or a conventional guide catheter works better for adults having a thrombectomy to treat an acute ischemic stroke.

  Recruiting at 2 sites University of South Florida · Tampa, Florida and 1 other locations · NCT07085390

• FRESH-EATS: a family healthy eating program.

  This program tries to see if FRESH-EATS helps children ages 8-12 and their parents/caregivers in low-income neighborhoods eat healthier.

  Recruiting University of South Florida · Tampa, Florida · NCT07053644

• Eating and drinking before urgent heart catheterization

  This trial will try whether letting adults with worsening angina or low-risk NSTEMI eat and drink before an urgent inpatient cardiac catheterization improves comfort without raising the chance of complications.

  Recruiting University of South Florida · Tampa, Florida · NCT06996639

• Palliative care education for dementia care providers in assisted living

  This study is testing whether training for nurses and caregivers in assisted living can improve the quality of care for people with dementia and make their jobs easier.

  Recruiting at 2 sites University of South Florida · Tampa, Florida and 1 other locations · NCT06722352

• Postpartum pelvic floor recovery with Leva

  This study tests whether a motion-based Leva device can help people 4–8 weeks after a vaginal birth rebuild pelvic floor strength and reduce bladder, bowel, and pelvic symptoms.

  Recruiting at 2 sites University of South Florida · Tampa, Florida and 1 other locations · NCT06609317

• Hyperbaric oxygen therapy for veterans with traumatic brain injury

  This study is testing if hyperbaric oxygen therapy can help veterans and active military personnel with mild to moderate traumatic brain injuries feel better and reduce symptoms of PTSD.

  Recruiting Phase 3 University of South Florida · Tampa, Florida · NCT06581003

• Web-based intervention to improve sleep in children with behavioral issues and their parents

  This study is testing a web-based program to help children with behavioral issues and their parents improve sleep and family dynamics.

  Recruiting University of South Florida · Tampa, Florida · NCT06410495

• Using a special medical food with standard treatment for advanced rectal cancer

  This study is testing a special medical food to see if it helps adults with advanced rectal cancer stick to their treatment plan while they receive standard radiation and chemotherapy.

  Recruiting University of South Florida · Tampa, Florida · NCT06380101

• How hearing aids affect understanding speech in noisy places

  This project will test whether different hearing-aid directional settings help older adults with sensorineural hearing loss understand speech in noisy environments and whether simple spatial hearing measures predict who benefits.

  Recruiting University of South Florida · Tampa, Florida · NCT06377215

• Telehealth sleep intervention for children with oppositional defiant disorder

  This study tests a new online sleep program for children with Oppositional Defiant Disorder and insomnia to see if it can help them sleep better and feel more focused during the day.

  Recruiting University of South Florida · Tampa, Florida · NCT06350292

• Improving sleep and reducing opioid use in people with chronic pain

  This study is testing if a sleep therapy can help people with chronic pain sleep better and use fewer opioids.

  Recruiting University of South Florida · Tampa, Florida · NCT06345872

• Recursive self-feedback to help speech after a stroke in aphasia

  Researchers are testing whether stroke survivors with aphasia can improve their everyday speech by listening to and correcting their own spoken responses using tablet-based, self-guided feedback.

  Recruiting University of South Florida · Tampa, Florida · NCT06323629

• Network for studying rare and atypical diabetes

  This study is trying to find and understand rare types of diabetes by testing people and families who haven't been diagnosed yet, using blood tests and genetic screening to learn more about these conditions.

  Recruiting at 13 sites University of South Florida · Aurora, Colorado and 12 other locations · NCT05544266

• Evaluating long-term effects of osseointegrated devices on hearing and cognition

  This study is trying to see how using special hearing devices affects the thinking and daily life of people with hearing loss over three years.

  Recruiting University of South Florida · Tampa, Florida · NCT04899037

• Web-based intervention for insomnia in rural dementia caregivers

  This study is testing a new online program to help rural caregivers of people with dementia improve their sleep and overall well-being.

  Recruiting University of South Florida · Tampa, Florida · NCT04896775

• Online cognitive behavioral therapy for insomnia in dementia caregivers

  This study tests if an online therapy program can help caregivers of people with dementia sleep better and improve their mood.

  Recruiting University of South Florida · Columbia, Missouri · NCT04632628

• ShuntCheck vs radionuclide shunt testing for suspected obstruction in adults with normal pressure hydrocephalus

  This study tests whether ShuntCheck can accurately detect CSF shunt flow issues in adults with suspected shunt obstruction due to normal pressure hydrocephalus.

  Recruiting University of South Florida · Tampa, Florida · NCT04309487

• Comparing pain from different numbers of bladder injections of Botox

  This study is testing whether getting 5 or 20 Botox injections for overactive bladder causes more pain in women who haven't found relief from other treatments.

  Recruiting at 2 sites Phase 4 University of South Florida · Washington D.C., District of Columbia and 1 other locations · NCT04305743

• ShuntCheck performance in people with normal pressure hydrocephalus

  This study tests whether the ShuntCheck test can reliably show flow or no flow in a ventriculoperitoneal shunt in adults with asymptomatic normal pressure hydrocephalus.

  Recruiting University of South Florida · Tampa, Florida · NCT04011566

• Using chloroquine to treat persistent atrial fibrillation

  This study is testing if chloroquine can help people with persistent atrial fibrillation get back to a normal heart rhythm within two weeks.

  Recruiting Phase 2 University of South Florida · Tampa, Florida · NCT02932007

• Combining oxymetazoline and fluticasone to improve sleep apnea symptoms

  This study is testing if using a nasal spray that combines two medications can help people with mild sleep apnea and nasal congestion breathe better at night.

  Recruiting Phase 4 University of South Florida · Tampa, Florida · NCT02630121

• Pathway to Prevention of Type 1 Diabetes

  This study is trying to see if a simple blood test can help identify people at risk for type 1 diabetes so they can be monitored and potentially prevent the disease.

  Recruiting at 19 sites University of South Florida · Orange, California and 21 other locations · NCT00097292

NIH-funded research (newest 40 of 323)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how cell signals control heart development in Down syndrome

  Scientists are studying why many babies with Down syndrome have heart defects and how interrupting specific signals in heart cells might prevent or lessen these problems.

  NIH research University of South Florida · Tampa, United States · NIH-11638027

• Multi-agent AI to annotate enzymes in the human gut microbiome

  A team at a major university will build an AI system that automatically curates and labels the functions of enzymes in the human gut microbiome to speed up understanding their health effects.

  NIH research University of South Florida · Tampa, United States · NIH-11594384

• P7C3-based small molecule to help the heart restore NAD+ and function

  A promising new approach aims to use P7C3-like small molecules to boost NAD+ in heart cells so people with heart failure could experience improved heart energy and function.

  NIH research University of South Florida · Tampa, United States · NIH-11590659

• Self-supervised deep learning for biological sequences

  A deep learning project uses self-supervised methods to better understand biological sequences and related data, with the goal of advancing biology and medicine.

  NIH research University of South Florida · Tampa, United States · NIH-11581695

• Environmental factors and early autoimmunity leading to type 1 diabetes in youth (TEDDY NCC2 follow-up)

  Researchers continue a long-running study to understand environmental triggers that start autoimmunity and progress to type 1 diabetes in children aged 6–15.

  NIH research University of South Florida · Tampa, United States · NIH-11557441

• T Lymphopenia After a Heart Attack: Could Restoring T Cells Help Your Heart Heal

  A study at the University of South Florida aims to understand why certain immune cells called CD4+ T cells drop after a heart attack and whether boosting them could improve heart recovery.

  NIH research University of South Florida · Tampa, United States · NIH-11550873

• Understanding how metabolic stress affects amyloid buildup in Alzheimer’s disease

  Researchers will use advanced computer models to explore how metabolic stress promotes amyloid beta aggregation in the brain, with potential implications for Alzheimer’s disease.

  NIH research University of South Florida · Tampa, United States · NIH-11537703

• Understanding how insecticide and drug resistance change malaria control

  This grant studies how mosquitoes and malaria parasites develop resistance to insecticides and drugs, with the goal of keeping malaria prevention and treatment effective for children in Africa.

  NIH research University of South Florida · Tampa, United States · NIH-11518530

• Understanding why malaria persists in Cameroon and how to stop it

  A study in Cameroon will track malaria transmission across different settings to identify which factors keep malaria a problem and how interventions could be made more effective for families and communities.

  NIH research University of South Florida · Tampa, United States · NIH-11518529

• Data Management and Biostatistics Core for malaria research

  A data management and biostatistics team helps malaria research in Africa by securely organizing data, performing analyses, and training local scientists.

  NIH research University of South Florida · Tampa, United States · NIH-11518528

• Administrative Core for a malaria research center in Africa

  A central administrative grant supports a collaborative malaria research program in Cameroon to guide better malaria control strategies.

  NIH research University of South Florida · Tampa, United States · NIH-11518527

• Unraveling what keeps malaria spreading in Cameroon

  This grant supports a multi-year effort to understand why malaria persists in Cameroon and how that knowledge can help reduce infections and resistance.

  NIH research University of South Florida · Tampa, United States · NIH-11512337

• How a change to the brain protein α‑synuclein differs between healthy people and Lewy body dementia

  Researchers are checking whether a specific chemical change (called S129 phosphorylation) on the brain protein α‑synuclein looks different in healthy brains compared with brains affected by Lewy body dementia and related conditions.

  NIH research University of South Florida · Tampa, United States · NIH-11507541

• Role of plasmacytoid dendritic cells in corneal immunity

  This research explores how a specific eye immune cell (plasmacytoid dendritic cells) helps keep the cornea calm and may prevent damaging inflammation.

  NIH research University of South Florida · Tampa, United States · NIH-11468519

• How corneal nerves and immune cells talk to protect vision

  The team aims to find how corneal immune and tissue cells keep corneal nerves alive and help recovery for people with neurotrophic keratitis.

  NIH research University of South Florida · Tampa, United States · NIH-11468518

• How well preschoolers who are deaf or hard of hearing access spoken language in everyday life

  This project measures how background noise and caregiver talk shape language access and brain responses in preschoolers who are deaf or hard of hearing compared with children who have typical hearing.

  NIH research University of South Florida · Tampa, United States · NIH-11456543

• eSANA: revealing and improving AAC use after stroke for aphasia

  A project to explore how people with aphasia after a stroke can best use augmentative and alternative communication (AAC) during early rehabilitation.

  NIH research University of South Florida · Tampa, United States · NIH-11454006

• New medicines aimed at the kappa opioid receptor

  Testing new kappa opioid receptor drugs to find ones that may help people with anxiety or severe itching without causing sedation or addiction.

  NIH research University of South Florida · Tampa, United States · NIH-11446171

• Biasing Mu Opioid Receptor Signaling in the Body

  Researchers are exploring how different medicines that target the mu opioid receptor can provide pain relief with fewer dangerous side effects, aiming to inform safer opioid therapies for patients.

  NIH research University of South Florida · Tampa, United States · NIH-11444754

• Cancer screening design for accurate ROC estimates using smart sampling

  A small research grant to improve how we confirm cancer screening results in high-risk people by using smarter two-phase sampling to estimate how well a test detects cancer.

  NIH research University of South Florida · Tampa, United States · NIH-11436938

• PPP1R3G and kidney transplant cell survival

  This project studies how a specific protein, PPP1R3G, affects kidney transplant cell survival after surgery to help grafts last longer.

  NIH research University of South Florida · Tampa, United States · NIH-11433911

• How the brain’s support structure around certain neurons may affect appetite and weight in Alzheimer’s-related conditions

  A new NIH grant explores whether a brain “support network” around specific neurons in a region linked to appetite could influence weight gain in people affected by Alzheimer’s disease and related dementia.

  NIH research University of South Florida · Tampa, United States · NIH-11430870

• Role of Pard3 in cornea cell polarity and health

  A project to understand how a protein called Pard3 helps the cornea maintain its surface structure and function, with studies in mice and human cornea cells.

  NIH research University of South Florida · Tampa, United States · NIH-11429022

• Decoding how secondary active transporters move substances across cell membranes

  A research project to understand how a family of cell membrane transporters works to move nutrients, drugs, and other important molecules into and out of cells.

  NIH research University of South Florida · Tampa, United States · NIH-11428311

• Brain m6A map in Alzheimer’s disease

  A study to map a common brain RNA modification (m6A) in people with Alzheimer’s disease to illuminate how this change might contribute to disease.

  NIH research University of South Florida · Tampa, United States · NIH-11418511

• Microvascular and Endothelial Health and Postoperative Atrial Fibrillation

  A heart-surgery study aims to understand how tiny blood vessels in the atria affect the risk of developing atrial fibrillation after surgery and what this means for patients.

  NIH research University of South Florida · Tampa, United States · NIH-11418469

• Restoring the cornea’s support layer to reduce scarring

  Researchers are trying to restore the cornea’s supporting tissue to help people with corneal scarring from injury, infection, or congenital conditions.

  NIH research University of South Florida · Tampa, United States · NIH-11418376

• CRISPR-based approach to slow vision loss in macular degeneration

  A doctor-scientist team at a US university is testing a CRISPR/Cas9 strategy to modify a gene (NRL) in retinal cells to slow vision loss from age-related macular degeneration.

  NIH research University of South Florida · Tampa, United States · NIH-11408663

• How mosquitoes and malaria parasites become resistant to insecticides and medicines

  This project follows mosquitoes and malaria parasites across different sites to find out why bed nets, sprays, and antimalarial drugs stop working for people at risk of malaria.

  NIH research University of South Florida · Tampa, United States · NIH-11404830

• Why malaria keeps spreading in parts of Cameroon

  This project looks at how local mosquito behavior and environmental conditions keep malaria common in Cameroonian communities, especially affecting children and their families.

  NIH research University of South Florida · Tampa, United States · NIH-11404827

• Why malaria keeps spreading in Cameroon

  A team is mapping how and where malaria keeps spreading in Cameroon to help protect local children and families.

  NIH research University of South Florida · Tampa, United States · NIH-11404823

• Ano4's role in body weight and glucose balance

  A scientists at the University of South Florida are studying how a brain ion channel called Ano4 in the area postrema influences food intake, body weight, and blood sugar in mice, to better understand obesity in people.

  NIH research University of South Florida · Tampa, United States · NIH-11402435

• Lac-Phe and brain signals that curb appetite in obesity

  Aims to understand how a blood molecule called Lac-Phe, boosted by exercise, helps reduce appetite and body fat by acting on brain cells in adults with obesity-related diabetes.

  NIH research University of South Florida · Tampa, United States · NIH-11402433

• Brain cells that control hunger and pleasure in obesity

  Researchers are studying a specific brain cell group to see how it boosts normal hunger-driven eating while reducing pleasure-driven eating, in the context of adult-onset diabetes and obesity.

  NIH research University of South Florida · Tampa, United States · NIH-11402432

• A brain channel's role in mother-infant bonding

  This project looks at whether a specific brain protein helps mothers bond with and care for their babies.

  NIH research University of South Florida · Tampa, United States · NIH-11402428

• Serotonin 2C receptor's role in Alzheimer’s symptoms

  This project is seeing whether changes in a brain serotonin receptor (5-HT2C) contribute to memory loss, social withdrawal, and aggression in people with Alzheimer’s and whether fixing that receptor could point to new treatments for them.

  NIH research University of South Florida · Tampa, United States · NIH-11402425

• Understanding Recovery in Alcohol Use Disorder Across Time and Drinking Levels

  This research explores how people recovering from alcohol use disorder define and experience recovery beyond simply stopping drinking.

  NIH research University of South Florida · Tampa, United States · NIH-11401211

• Arachidonic acid metabolism and the tumor immune environment in colorectal cancer

  This project looks at how fats called arachidonic acids may influence immune cells inside colorectal tumors, with the goal of finding new ways to help treat cancer.

  NIH research University of South Florida · Tampa, United States · NIH-11400307

• How bacteria build their protective shell and how this happens in time

  A study in friendly terms that looks at how bacteria assemble their cell envelopes in a coordinated way during growth, using new microscopy to understand where surface proteins go to the cell wall.

  NIH research University of South Florida · Tampa, United States · NIH-11396539

• BIN1 in microglia and Alzheimer's disease: how a immune cell protein shapes inflammation

  This grant studies how BIN1, a protein in brain immune cells, affects inflammation and Alzheimer’s disease risk.

  NIH research University of South Florida · Tampa, United States · NIH-11396508

Quick answers

How many clinical trials run by University of South Florida are recruiting right now?

39, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (39 trials), Australia (1 trial), Canada (1 trial), Finland (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 1: 1, Phase 3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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