Decoding how secondary active transporters move substances across cell membranes
Official title: Decoding Ion Coupling and Design Principles of Secondary Active Transporters
Funded at University of South Florida · NIH-11428311 · Data updated 2026-11-12
A research project to understand how a family of cell membrane transporters works to move nutrients, drugs, and other important molecules into and out of cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $412,500 |
| NIH project number | 1R35GM165890-01 |
| Project ID | NIH-11428311 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable here as this is a basic science grant; future patient-informed work may emerge from the findings.
✕Less likely to help
No direct patient impact expected during the initial basic-science project.
What this research studies
If funded, researchers will study how solute carriers (SLCs) switch shapes to move substrates across membranes and how they use energy from ion gradients to drive this movement. The work combines structural biology, biophysics, bioinformatics, and functional genomics over five years to map transporter states and energy use. The goal is to translate these basic insights into better understanding of human diseases linked to SLCs and how drugs reach target tissues. This could eventually inform patient treatments and precision medicine approaches.
Why it matters
Potential benefit: Improved understanding of transporter function could lead to better drugs and therapies with more predictable how they reach cells.
How similar studies have gone: Previous studies have advanced knowledge of transporter mechanisms, showing this approach can yield meaningful mechanistic insights.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Reddy, Krishna D — University of South Florida
- Study coordinator: Reddy, Krishna D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.