Understanding how metabolic stress affects amyloid buildup in Alzheimer’s disease
Official title: Investigating the aggregation of amyloid β during metabolic stress using multiscale modeling
Funded at University of South Florida · NIH-11537703 · Data updated 2026-11-12
Researchers will use advanced computer models to explore how metabolic stress promotes amyloid beta aggregation in the brain, with potential implications for Alzheimer’s disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $678,424 |
| NIH project number | 4R33AG087910-03 |
| Project ID | NIH-11537703 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with Alzheimer’s disease or those at risk due to metabolic stress-related brain events may benefit from insights that guide future therapies.
✕Less likely to help
This project is primarily modeling-based and does not involve direct patient testing at this stage.
What this research studies
This project uses multiscale computer modeling to examine how conditions like low pH and high ion concentrations, which occur during metabolic stress, influence the formation of toxic amyloid aggregates linked to Alzheimer’s disease. By simulating different brain environments, the team aims to map how short bursts of stress could create distinct amyloid aggregates. The goal is to identify critical factors and time windows that drive harmful aggregation, informing future experimental studies and potential interventions.
Why it matters
Potential benefit: If successful, the work could help identify new targets or strategies to prevent harmful amyloid aggregation in Alzheimer’s disease.
How similar studies have gone: Previous research shows amyloid aggregation is influenced by environmental conditions, and modeling has provided insights in other neurodegenerative contexts; this study extends those ideas to metabolic stress scenarios.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Ullah, Ghanim — University of South Florida
- Study coordinator: Ullah, Ghanim
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.