PPP1R3G and kidney transplant cell survival
Official title: PPP1R3G and transplanted renal graft function
Funded at University of South Florida · NIH-11433911 · Data updated 2026-11-12
This project studies how a specific protein, PPP1R3G, affects kidney transplant cell survival after surgery to help grafts last longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | August 20, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $736,882 |
| NIH project number | 1R01DK148851-01 |
| Project ID | NIH-11433911 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with end-stage kidney disease who are candidates for kidney transplantation and may receive a transplant from a deceased or living donor.
✕Less likely to help
Patients not eligible for kidney transplantation or whose grafts do not experience ischemia-reperfusion injury may see limited direct benefit.
What this research studies
Kidney transplant patients may experience cell death in the new kidney due to injury around the time of transplant. The study looks at how PPP1R3G and RIPK1 interact to influence cell death and inflammation in transplanted kidneys. By understanding these pathways, researchers aim to identify targets that could reduce injury and improve long-term graft function. This work could lead to new approaches to protect transplanted kidneys from ischemia-reperfusion injury.
Why it matters
Potential benefit: If successful, findings could lead to therapies that improve kidney graft survival and reduce delayed function after transplantation.
How similar studies have gone: Previous research supports the role of RIPK1 signaling in kidney injury, and this study builds on that to identify PPP1R3G-related mechanisms.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Wang, Lei — University of South Florida
- Study coordinator: Wang, Lei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.