Environmental factors and early autoimmunity leading to type 1 diabetes in youth (TEDDY NCC2 follow-up)
Official title: Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)
Funded at University of South Florida · NIH-11557441 · Data updated 2026-11-12
Researchers continue a long-running study to understand environmental triggers that start autoimmunity and progress to type 1 diabetes in children aged 6–15.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | August 15, 2026 |
| Project end | December 31, 2026 |
| Funding year | 2026 |
| Award (this year) | $6,155,276 |
| NIH project number | 3U01DK128847-04SA |
| Project ID | NIH-11557441 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and adolescents aged 6–15 who are part of or at risk for the TEDDY study and their families.
✕Less likely to help
Participants not at risk for autoimmune progression or who do not contribute to NCC2 analyses may see no direct benefit.
What this research studies
This grant funds continued data management, lab support, and planning meetings for the TEDDY study, focusing on how exposures may trigger autoimmunity and diabetes in young people. It supports completing datasets and analyzing a second case-control cohort (NCC2) to study initiation of autoimmunity and progression to diabetes in 6- to 15-year-old participants. The work involves environmental data collection, laboratory storage, and collaborative discussions to guide future analyses. The goal is to identify factors that could help prevent or delay type 1 diabetes in kids who are at risk.
Why it matters
Potential benefit: If successful, findings could inform strategies to prevent or delay type 1 diabetes in children at risk.
How similar studies have gone: Previous TEDDY research has identified environmental exposures linked to autoimmunity; this grant builds on that foundation with continued follow-up.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Krischer, Jeffrey P — University of South Florida
- Study coordinator: Krischer, Jeffrey P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.