P7C3-based small molecule to help the heart restore NAD+ and function
Official title: P7C3 based small molecule for Heart failure treatment
Funded at University of South Florida · NIH-11590659 · Data updated 2026-11-12
A promising new approach aims to use P7C3-like small molecules to boost NAD+ in heart cells so people with heart failure could experience improved heart energy and function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 5, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $488,975 |
| NIH project number | 4R33HL170457-03 |
| Project ID | NIH-11590659 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be adults with heart failure or at risk of heart failure who may benefit from therapies targeting NAD+ activation.
✕Less likely to help
Patients without heart failure or those with conditions not related to NAD+ metabolism may not experience benefit.
What this research studies
This project focuses on developing and testing new P7C3-based compounds that activate NAD+ production to support heart cell health. Researchers will design and screen molecules in lab tests, then evaluate the best candidates in ex vivo heart preparations and in animal models of heart failure. The goal is to identify lead compounds that improve heart metabolism and function with a clear path toward future studies in patients who have heart failure.
Why it matters
Potential benefit: If successful, this research could yield new drugs that strengthen heart energy use and function in people with heart failure.
How similar studies have gone: Previous work with related compounds has shown potential to modify heart metabolism, but this is a novel lead series with preclinical progression.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Tipparaju, Srinivas M. — University of South Florida
- Study coordinator: Tipparaju, Srinivas M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.