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Clinical trials and research at The Hospital for Sick Children

• 51Clinical trials
• 20Countries

Newest trials

All recruiting trials (51)

• Climate-responsive nutrition, WASH, and heat counselling for maternal and child health in Sindh

  A community-based program will test whether training local health workers and facility staff to give climate-aware nutrition, hygiene, and heat adaptation guidance improves maternal and child nutrition outcomes in rural Sindh, Pakistan.

  Recruiting The Hospital for Sick Children · Karachi, Sindh · NCT07819994

• Supporting siblings of kids with complex medical needs

  This study tests a mental-health support model for siblings aged 10–17 of children with medical complexity.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT07756502

• Comparing Two Ureteral Stent Designs in Children with Kidney Stones

  This study tests whether two common ureteral stents lead to different comfort and urinary symptoms in kids undergoing stone treatment.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT07742358

• MedlyPeds: a smartphone app to monitor kids with heart disease

  This study tests whether the MedlyPeds app can help kids with heart conditions and their families stay informed and track symptoms remotely.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT07556185

• Complete Cognitive Support for childhood-onset lupus

  This program will try an online problem-solving course to help thinking and everyday functioning in teens (13–18) with childhood-onset lupus.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT07302113

• AI role-play versus peer role-play to teach informed consent for endoscopy

  This project tests whether AI-based virtual patient role-play or peer role-play better teaches University of Toronto physician trainees to obtain informed consent for endoscopic procedures.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT07069504

• Optimizing nutrition for very low birth weight infants

  This study looks at how the nutrition from human milk affects the growth and health of very low birth weight infants to help create better feeding plans for them.

  Recruiting at 2 sites The Hospital for Sick Children · Palo Alto, California and 5 other locations · NCT06870981

• IV magnesium for children with severe asthma attacks in the emergency department

  This trial will test whether a single 30-minute IV magnesium infusion helps children aged 2–17 with moderate–severe asthma after standard ED treatment breathe better and avoid hospital admission.

  Recruiting Phase 3 The Hospital for Sick Children · Calgary, Alberta and 5 other locations · NCT06785272

• Using sugar water to reduce pain in infants during throat scopes

  This study is testing if giving sugar water to infants can help reduce their pain and discomfort during a throat examination.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT06641687

• Teaching parents to test breastmilk sodium levels in preterm infants

  This study is testing if teaching parents how to check the sodium levels in their breastmilk can help improve milk production for their preterm babies.

  Recruiting at 2 sites The Hospital for Sick Children · Seattle, Washington and 1 other locations · NCT06563726

• Personalized medicine network for childhood arthritis and rheumatic disease

  This study is trying to find out how to better treat children with juvenile idiopathic arthritis by collecting information and samples to help doctors choose the right medications at the right time.

  Recruiting at 19 sites The Hospital for Sick Children · Calgary, Alberta and 18 other locations · NCT06560606

• Deep brain stimulation for severe self-injurious behavior in children with autism

  This study is testing if deep brain stimulation can help children with autism who struggle with severe self-injurious behavior feel better.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT06529380

• Observing pediatric patients who have stopped using parenteral nutrition

  This study looks at children who have stopped using parenteral nutrition to see what health issues they might face afterward and to find out which kids are most at risk.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT06525753

• Investigating immune therapy for children and young adults with specific brain tumors

  This study is testing if a new immune therapy called nivolumab can help children and young adults with certain brain tumors avoid or delay radiation treatment.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT06519682

• Mediterranean-style diet for children with juvenile arthritis

  This study will try a Mediterranean-style diet in children aged 8–18 with juvenile idiopathic arthritis to see if it improves arthritis symptoms and changes the gut microbiome.

  Recruiting at 4 sites The Hospital for Sick Children · Winnipeg, Manitoba and 6 other locations · NCT06474546

• Program to support parents in promoting healthy behaviors in children

  This study tests whether a program that helps parents promote healthy eating, exercise, and sleep can improve the health and well-being of children aged 2-5 years.

  Recruiting at 2 sites The Hospital for Sick Children · Toronto, Ontario and 1 other locations · NCT06389084

• Combination treatment of vinblastine and tovorafenib for young patients with recurrent low-grade gliomas

  This study is testing a combination of two drugs, vinblastine and tovorafenib, to see if it can help young patients with recurring low-grade brain tumors feel better.

  Recruiting Early Phase 1 The Hospital for Sick Children · Toronto, Ontario · NCT06381570

• Isoleucine, leucine, valine and tryptophan needs in newborns on TPN

  This project will test how much isoleucine, leucine, valine, and tryptophan newborns who are fully fed by TPN need to support growth and normal metabolism.

  Recruiting The Hospital for Sick Children · Santa Maria · NCT06372314

• Determining the dietary tryptophan needs of older adults

  This study is testing how much tryptophan older adults need in their diet to stay healthy and support their body's protein needs.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT06283706

• Determining threonine needs in older adults

  This study is testing how much threonine older adults need in their diet to keep their gut health strong as they age.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT06225648

• Evaluating kidney and blood pressure outcomes in childhood cancer survivors

  This study is trying to see how common kidney problems and high blood pressure are in childhood cancer survivors a few years after their treatment.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT06153147

• Online program to help Canadian youth manage chronic pain

  This study is testing an online program to help Canadian youth with chronic pain learn to manage their symptoms and improve their mental health.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT06076889

• Virtual support program for parents of children with congenital heart disease

  This study is testing a virtual support program to see if it can help parents of young children with congenital heart disease improve their parenting skills and their child's behavior compared to regular care.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT06075251

• Virtual mentorship program for parents of pediatric organ transplant recipients

  This study tests whether a virtual mentorship program can help parents of children who have had organ transplants feel less alone and improve their mental health.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT05968807

• Monitoring heart function in children using smart textiles

  This study is testing a new smart textile device to see if it can safely and effectively monitor heart function in children staying in the hospital.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT05961176

• Virtual care program for youth with chronic pain

  This study tests an online program that helps young people manage their chronic pain while they wait for specialized care to see if it improves their pain and mental health.

  Recruiting at 2 sites The Hospital for Sick Children · Halifax, Nova Scotia and 10 other locations · NCT05894772

• Home initiation of breathing support for children with complex medical needs

  This study is testing if starting breathing support at home for children with complex medical needs is safe and effective compared to starting it in the hospital.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT05881031

• Online peer support mentorship for teens with heart failure

  This study is testing an online program that connects teens with heart failure to young adult mentors to see if their support helps the teens manage their condition better.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT05709132

• Evaluating L-Citrulline for Preterm Infants with Lung and Gut Issues

  This study is testing if giving L-Citrulline to preterm infants with lung and gut problems can help reduce inflammation and improve their health.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT05636397

• Assessing amino acid needs in neonates on total parenteral nutrition

  This study is trying to find out how much of three important amino acids babies on total parenteral nutrition need to stay healthy.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT05562310

• Reduced toxicity conditioning for high-risk thalassemia treatment

  This study is testing a new transplant method to see if it can safely help children with high-risk thalassemia by reducing side effects and improving their chances of recovery.

  Recruiting Phase 1/2 The Hospital for Sick Children · Toronto, Ontario · NCT05426252

• Using advanced imaging to study retinal disorders

  This study is testing a new imaging technology to see how it can help understand and track changes in the eyes of people with inherited and acquired retinal disorders.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT05386134

• iCanCope PostOp app to help teens manage pain after scoliosis or pectus surgery

  This project will test whether the iCanCope PostOp smartphone app helps teens aged 12–18 manage pain and recovery after scoliosis or minimally invasive pectus surgery.

  Recruiting The Hospital for Sick Children · Boston, Massachusetts and 1 other locations · NCT05382962

• Using Metformin to Improve Brain Function in Children with Medulloblastoma

  This study is testing if metformin can help improve brain function and growth in children and teens aged 7 to 20 who have finished treatment for medulloblastoma.

  Recruiting at 19 sites Phase 3 The Hospital for Sick Children · New Lambton Heights, New South Wales and 19 other locations · NCT05230758

• Registry for fetal Ebstein anomaly and tricuspid valve dysplasia

  This study is collecting information from mothers of unborn babies with Ebstein anomaly and tricuspid valve dysplasia to see how best to care for these serious heart conditions.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT05225311

• Feasibility of a new approach to control nausea in children with leukemia

  This study is testing a new program to help parents learn how to better manage nausea in children with leukemia who are undergoing chemotherapy.

  Recruiting at 4 sites The Hospital for Sick Children · Los Angeles, California and 3 other locations · NCT04929899

• Long-term outcomes of hip interventions for children with cerebral palsy

  This study looks at different treatments for hip problems in children with severe cerebral palsy to see how they can improve their quality of life.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT04792606

• Measuring threonine needs in adult males with Crohn's disease

  This study is trying to find out how much threonine adult men with Crohn's disease need compared to healthy young adults.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT04740541

• Pectoral nerve block versus local numbing for children getting chest pacemaker or ICD placement

  This test will see if giving a pectoral nerve block before implant surgery helps children need fewer opioids after chest device placement than local numbing alone.

  Recruiting Phase 4 The Hospital for Sick Children · Toronto, Ontario · NCT04577690

• Registry for Fetal Immune-mediated Heart Block

  This study is trying to see how different treatments for fetuses with a serious heart condition affect their health and survival as they grow up.

  Recruiting at 27 sites The Hospital for Sick Children · Phoenix, Arizona and 26 other locations · NCT04559425

• Understanding kidney toxicity from Cisplatin in cancer patients

  This study is testing how Cisplatin, a common chemotherapy drug, affects kidney health in both adult and child cancer patients to find early signs of kidney damage and improve treatment outcomes.

  Recruiting The Hospital for Sick Children · London, Ontario · NCT04442516

• Evaluating different overnight duty schedules for ICU residents

  This study tests whether different overnight work schedules for ICU residents can improve patient safety and the learning experience for doctors in training.

  Recruiting The Hospital for Sick Children · Toronto, Ontario and 4 other locations · NCT04176094

• Metformin to activate neural progenitor cells in children and young adults with MS

  This trial will try giving metformin or placebo to children and young adults with MS to see if metformin helps the brain cells that repair myelin.

  Recruiting Phase 1/2 The Hospital for Sick Children · Toronto, Ontario · NCT04121468

• Using Xenon-129 MRI to Study Lung Function in Healthy and Diseased Lungs

  This study is testing a new type of MRI using a special gas to see if it can help us understand lung function better in people with cystic fibrosis and asthma compared to healthy individuals.

  Recruiting Phase 2 The Hospital for Sick Children · Toronto, Ontario · NCT02740868

• Understanding Inflammatory Bowel Disease in Canadian Children

  This study looks at why more kids in Canada are getting Inflammatory Bowel Disease and tries to find out how things like environment and genetics affect their health and treatment.

  Recruiting at 12 sites The Hospital for Sick Children · Calgary, Alberta and 11 other locations · NCT02308917

• Registry for rare histiocytic disorders

  This study is gathering information from people of all ages with rare histiocytic disorders to help improve diagnosis and treatment options.

  Recruiting at 14 sites The Hospital for Sick Children · Birmingham, Alabama and 14 other locations · NCT02285582

• Comparing treatments for simple bone cysts in children

  This study is testing which treatment works better for simple bone cysts in children: one that uses a curettage and puncture alone or one that adds an injection of Vitoss morsels.

  Recruiting at 16 sites Phase 3 The Hospital for Sick Children · Birmingham, Alabama and 24 other locations · NCT02193841

• Measuring nutrition in young preschool children in primary care

  This study looks at how nutrition affects the health of young children aged 0-5 to help doctors provide better care and promote healthier outcomes for kids.

  Recruiting at 3 sites The Hospital for Sick Children · Toronto, Ontario and 2 other locations · NCT01869530

• Longitudinal study of childhood nephrotic syndrome

  This study looks at children with nephrotic syndrome to see how genetics, blood tests, and environmental factors affect the condition and its progression over time.

  Recruiting at 4 sites The Hospital for Sick Children · Brampton, Ontario and 3 other locations · NCT01605266

• Evaluation of a program for managing obesity in children and adolescents

  This study is testing a special program to help children and teens with severe obesity to see if it improves their health and happiness compared to those who don’t join the program.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT01515904

• International Pediatric Stroke Study for infants and children

  This study is gathering information about infants and children who have had strokes or are at risk for them to help improve treatment and outcomes for pediatric stroke care.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT00084292

Quick answers

How many clinical trials run by The Hospital for Sick Children are recruiting right now?

51, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in Canada (48 trials), United States (7 trials), Netherlands (3 trials), Australia (2 trials), Germany (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 3, Phase 1/2: 2, Phase 4: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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