International Pediatric Stroke Study for infants and children
Official title: International Pediatric Stroke Study
Run by The Hospital for Sick Children · NCT00084292 · Data updated 2026-11-12
This study is gathering information about infants and children who have had strokes or are at risk for them to help improve treatment and outcomes for pediatric stroke care.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 18 Years |
| Sex | All |
| Enrollment | 12000 (estimated) |
| Sponsor | The Hospital for Sick Children Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Status | Recruiting |
| Started | January 2003 |
| Main results expected | December 2030 |
| Study ends | December 2030 |
| Registry record updated | May 15, 2025 |
| Trial ID | NCT00084292 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include infants and children up to 18 years old diagnosed with ischemic or hemorrhagic strokes or those at high risk for stroke.
✕Probably not a fit
Patients who are premature and diagnosed with certain stroke types or those who refuse consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The International Pediatric Stroke Study (IPSS) is a global registry established to collect and analyze data on infants and children who have experienced strokes or are at high risk for them. This multi-center, multi-national initiative involves over 100 institutions worldwide and aims to improve understanding, prevention, and outcomes of pediatric strokes. Participants' medical records are reviewed and entered into a secure database, allowing for collaborative research and analysis of stroke characteristics, treatment, and outcomes. The study focuses on building a comprehensive dataset to facilitate future research and clinical trials in pediatric stroke care.
Why it matters
Potential benefit: If successful, this study could lead to improved prevention and treatment strategies for pediatric strokes, ultimately enhancing patient outcomes.
How similar studies have gone: Other studies have shown success in similar approaches, but the IPSS represents a novel and comprehensive effort in pediatric stroke research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: This registry will include all children from birth to 18 years of age who are diagnosed with stroke or a condition/disease (as defined below) that put them at high risk of stroke after Jan 1,2003 at one of the IPSS participating sites. This registry will include children diagnosed with below stroke types: * Arterial Ischemic Stroke (AIS), * Cerebral Sinovenous Thrombosis (CSVT), * AIS and CSVT * Presume Preinatal Ischemic Stroke (PPIS) * Children diagnosed with hemorrhagic stroke Children at high risk of stroke include: * Those diagnosed with arteriopathy, arteritis/vasculitis, moyamoya, dissection, sickle cell related infarcts). * Brain arteriovenous malformations Exclusion Criteria: * Premature children diagnosed with AIS. * Premature children diagnosed with PPIS * Children diagnosed with TIA (Transient Ischemic Attack) * Brain hemorrhage secondary to trauma * Refusal to provide consent for participation
Where it's running
-
Hospital For Sick Children
Toronto, Ontario, Canada Recruiting
Study contacts
- Principal investigator: Nomazulu Dlamini, MD — The Hospital for Sick Children
- Study coordinator: IPSS Central
- Email: ipss.research@sickkids.ca
- Phone: 416-813-7654
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.