International Pediatric Stroke Study for infants and children
International Pediatric Stroke Study
This study is gathering information about infants and children who have had strokes or are at risk for them to help improve treatment and outcomes for pediatric stroke care.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 12000 (estimated) |
| Ages | N/A to 18 Years |
| Sex | All |
| Sponsor | The Hospital for Sick Children Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT00084292 on ClinicalTrials.gov |
What this trial studies
The International Pediatric Stroke Study (IPSS) is a global registry established to collect and analyze data on infants and children who have experienced strokes or are at high risk for them. This multi-center, multi-national initiative involves over 100 institutions worldwide and aims to improve understanding, prevention, and outcomes of pediatric strokes. Participants' medical records are reviewed and entered into a secure database, allowing for collaborative research and analysis of stroke characteristics, treatment, and outcomes. The study focuses on building a comprehensive dataset to facilitate future research and clinical trials in pediatric stroke care.
Who should consider this trial
Good fit: Ideal candidates include infants and children up to 18 years old diagnosed with ischemic or hemorrhagic strokes or those at high risk for stroke.
Not a fit: Patients who are premature and diagnosed with certain stroke types or those who refuse consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prevention and treatment strategies for pediatric strokes, ultimately enhancing patient outcomes.
How similar studies have performed: Other studies have shown success in similar approaches, but the IPSS represents a novel and comprehensive effort in pediatric stroke research.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: This registry will include all children from birth to 18 years of age who are diagnosed with stroke or a condition/disease (as defined below) that put them at high risk of stroke after Jan 1,2003 at one of the IPSS participating sites. This registry will include children diagnosed with below stroke types: * Arterial Ischemic Stroke (AIS), * Cerebral Sinovenous Thrombosis (CSVT), * AIS and CSVT * Presume Preinatal Ischemic Stroke (PPIS) * Children diagnosed with hemorrhagic stroke Children at high risk of stroke include: * Those diagnosed with arteriopathy, arteritis/vasculitis, moyamoya, dissection, sickle cell related infarcts). * Brain arteriovenous malformations Exclusion Criteria: * Premature children diagnosed with AIS. * Premature children diagnosed with PPIS * Children diagnosed with TIA (Transient Ischemic Attack) * Brain hemorrhage secondary to trauma * Refusal to provide consent for participation
Where this trial is running
Toronto, Ontario
- Hospital For Sick Children — Toronto, Ontario, Canada (Recruiting)
Study contacts
- Principal investigator: Nomazulu Dlamini, MD — The Hospital for Sick Children
- Study coordinator: IPSS Central
- Email: ipss.research@sickkids.ca
- Phone: 416-813-7654
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.