Using advanced imaging to study retinal disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the underlying retinal abnormalities in patients with inherited and acquired retinal disorders using adaptive optics (AO) technology. Approximately 200 participants, including a control group, will be recruited to undergo detailed retinal imaging and assessments. The study will track changes in retinal structures before and after various treatments, helping to establish AO imaging as a potential outcome measure for these conditions. Participants will have follow-up visits at 6 months and 1 year to monitor their progress.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Consent provided
2. Aged 5 - 70 years
3. Diagnosed with well documented retinal disorder

Control group Inclusion Criteria:

1. Subjects aged 5 years - 70 years with normal eye examination.
2. Patients with strabismus and otherwise normal visual acuity and eye examination
3. Patients with unilateral eye diseases such as cataract, with a normal eye exam in the fellow eye.

Exclusion Criteria:

1. Inability of the subject to maintain a stable position while seated
2. Uncontrolled nystagmus, trembling or movements of the eyes or the head
3. Presence of cataract or any opacity in the front of the eye that obscures retinal imaging
4. Any general disease such neurological disease which could affect vision and the retina.
5. History of previous uveitis, glaucoma, previous intra-ocular surgery or photodynamic therapy
6. High refractive errors (\> +15D or \< -15D) that cannot be corrected by the adaptive optics system.
7. Patients who have a history of photosensitivity or take any medicine that cause photosensitivity as a side effect
8. Patients who are aphakic after cataract surgery

Where it's running

• The Hospital for Sick Children
  Toronto, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Ajoy Vincent, MS — Associate Professor
• Study coordinator: Ajoy Vincent, MS
• Email: ajoy.vincent@sickkids.ca
• Phone: 416-813-1500

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.