Using advanced imaging to study retinal disorders
Adaptive Optics Imaging in Retinal Disorders
This study is testing a new imaging technology to see how it can help understand and track changes in the eyes of people with inherited and acquired retinal disorders.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 5 Years to 70 Years |
| Sex | All |
| Sponsor | The Hospital for Sick Children Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT05386134 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the underlying retinal abnormalities in patients with inherited and acquired retinal disorders using adaptive optics (AO) technology. Approximately 200 participants, including a control group, will be recruited to undergo detailed retinal imaging and assessments. The study will track changes in retinal structures before and after various treatments, helping to establish AO imaging as a potential outcome measure for these conditions. Participants will have follow-up visits at 6 months and 1 year to monitor their progress.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 5 to 70 years diagnosed with well-documented inherited or acquired retinal diseases.
Not a fit: Patients with significant eye movement disorders or other conditions that prevent stable imaging may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of retinal disorders and improve treatment outcomes through better monitoring of retinal changes.
How similar studies have performed: Other studies utilizing adaptive optics imaging have shown promise in understanding retinal diseases, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Consent provided 2. Aged 5 - 70 years 3. Diagnosed with well documented retinal disorder Control group Inclusion Criteria: 1. Subjects aged 5 years - 70 years with normal eye examination. 2. Patients with strabismus and otherwise normal visual acuity and eye examination 3. Patients with unilateral eye diseases such as cataract, with a normal eye exam in the fellow eye. Exclusion Criteria: 1. Inability of the subject to maintain a stable position while seated 2. Uncontrolled nystagmus, trembling or movements of the eyes or the head 3. Presence of cataract or any opacity in the front of the eye that obscures retinal imaging 4. Any general disease such neurological disease which could affect vision and the retina. 5. History of previous uveitis, glaucoma, previous intra-ocular surgery or photodynamic therapy 6. High refractive errors (\> +15D or \< -15D) that cannot be corrected by the adaptive optics system. 7. Patients who have a history of photosensitivity or take any medicine that cause photosensitivity as a side effect 8. Patients who are aphakic after cataract surgery
Where this trial is running
Toronto, Ontario
- The Hospital for Sick Children — Toronto, Ontario, Canada (Recruiting)
Study contacts
- Principal investigator: Ajoy Vincent, MS — Associate Professor
- Study coordinator: Ajoy Vincent, MS
- Email: ajoy.vincent@sickkids.ca
- Phone: 416-813-1500
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.