Observing pediatric patients who have stopped using parenteral nutrition
Official title: Weaning is Winning? (WeWin Study): Are Parenteral Nutrition (PN) Graduates Growing up Healthy?
Run by The Hospital for Sick Children · NCT06525753 · Data updated 2026-11-12
This study looks at children who have stopped using parenteral nutrition to see what health issues they might face afterward and to find out which kids are most at risk.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 0 Years to 18 Years |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | The Hospital for Sick Children Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Status | Recruiting |
| Started | June 1, 2024 |
| Main results expected | June 1, 2029 |
| Study ends | June 1, 2034 |
| Registry record updated | June 24, 2026 |
| Trial ID | NCT06525753 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are pediatric patients under 18 years old who have been off parenteral nutrition for at least one year and have a history of intestinal failure.
✕Probably not a fit
Patients who do not provide consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter prospective study focuses on pediatric patients with intestinal failure who have successfully weaned off parenteral nutrition. The research aims to assess the frequency and types of complications that may arise after discontinuing parenteral nutrition, as well as identifying which patients are at the highest risk for these complications. By gathering data on these patients, the study seeks to improve understanding of post-weaning health outcomes and quality of life. The study will involve monitoring these patients over time to gather comprehensive data on their health status.
Why it matters
Potential benefit: If successful, this study could enhance the management and quality of life for pediatric patients who have transitioned off parenteral nutrition.
How similar studies have gone: While there have been studies on complications related to parenteral nutrition, this specific focus on post-weaning outcomes in pediatric patients is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Parenteral Nutrition graduates for at least 1 year, with a history of intestinal failure. * Age \<18 years at time of inclusion. Exclusion criteria: * No consent provided.
Where it's running
-
The Hospital for Sick Children
Toronto, Ontario, Canada Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Resting energy tests in people with normal digestion vs. intestinal failure
This study tests resting energy expenditure in adults with and without intestinal failure to help tailor nutrition needs.
-
Anabolic response to IV amino acids in people with chronic intestinal failure
This will test whether giving IV amino acids helps people with chronic intestinal failure on home parenteral nutrition build and maintain body protein and better match their individual protein needs.
-
AI-guided IV nutrition for newborns in the NICU
This project will try an AI tool that suggests IV nutrition (TPN) for newborns in the NICU who cannot feed by mouth to see if it helps clinicians order the right formula more quickly and accurately.
-
AGE buildup in people starting long-term parenteral nutrition
This study checks whether adults and kids starting long-term parenteral nutrition accumulate more advanced glycation end-products over a year by non-invasive skin measurements.
-
Evaluating NTCB02-1 for patients needing parenteral nutrition
This study is testing a new nutritional treatment called NTCB02-1 to see if it helps patients who need feeding through an IV feel better compared to the standard treatment.
-
Improving nutrition in critically ill patients with gastrointestinal issues
This study tests if combining two types of nutrition methods can help critically ill patients with gut issues get the right amount of food they need to recover.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.