Sponsor or institution
Clinical trials and research at Lurie Children's Hospital of Chicago
As of November 12, 2026, Find a Trial lists 144 NIH-funded research projects at this institution, with $85.7 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 144NIH research projects
NIH-funded research (newest 40 of 144)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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UMPIRE: Better Urologic Care for Babies with Spina Bifida
This grant tests how to best protect kidney function in newborns with spina bifida by comparing and refining urologic care practices across multiple hospitals.
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National Spina Bifida Patient Registry at Lurie Children's Hospital
A long-term registry program collects health data from children and adults with spina bifida to understand how different treatments affect outcomes.
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Testing medicines for pediatric brain tumors in mice using patient-derived tumors
This project tests new drugs for childhood brain tumors in patient-derived mouse models to see which treatments may help kids in the future.
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Cardiovascular health in the offspring of pregnancies affected by gestational glucose and weight
This study follows young adults whose mothers had gestational diabetes or related conditions to understand how pregnancy health affects their heart and blood vessel health over time.
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PrEP use for Black cisgender women: making HIV prevention more accessible
This project tests practical strategies to help Black cisgender women in six U.S. counties start and keep using HIV PrEP.
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Intestinal macrophages and blood vessel growth in newborns to prevent NEC
This grant studies how infant gut immune cells and blood vessels interact and proposes ways to prevent a dangerous newborn intestinal disease.
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Advancing Acute Respiratory Infection Care for Kids on Home Ventilators
This grant aims to improve how doctors and families manage acute respiratory infections in children who rely on invasive long-term home ventilation.
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Mind-body care for kids with abdominal pain
A digital mindfulness program for children, teens, and young adults with abdominal pain and related symptoms is being tested to help reduce symptoms and improve daily life.
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Targeting aging-related blood vessel injury to prevent ARDS in older lungs
Aims to find ways to protect lung blood vessels in older adults to prevent dangerous lung swelling (ARDS).
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AYA Oncology Self-Care Movement: influencer-driven social media for oral chemo adherence
A tailored social‑media intervention led by influencers helps adolescents and young adults with acute lymphoblastic leukemia take their oral chemotherapy more consistently.
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Diabetes surveillance network using electronic health records in the Chicago area
A nationwide diabetes monitoring effort is expanding to Chicago to use electronic health records to identify and track diabetes cases, complications, and treatment patterns in youth and young adults.
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Carbonic Anhydrase–Linked Changes in Cell Transport and Infection in Cystic Fibrosis
A clinician-scientist is studying how a specific enzyme affects lung cell movement and bacterial sticking in cystic fibrosis to find new ways to reduce infections.
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Symptom-based questions to map how common food allergies are in the population
A validated, symptom-based questionnaire will be tested to reliably estimate how common IgE-mediated food allergies are in both children and adults across the United States.
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Long-term endotypes of prematurity-related lung disease in former preemies
A long-term study looking at why some babies born very early develop lasting breathing problems and how their genes might explain these different paths.
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Multidimensional view of how regulatory T cells behave in kids with severe viral pneumonia
A doctor-scientist program aims to understand how regulatory T cells influence recoveries from severe viral pneumonia in children, with results that could lead to better treatments.
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Lurie Children's Spina Bifida Patient Registry
This project collects health information over time from children and adults with spina bifida to compare care approaches and help doctors learn what works best.
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Protecting kidney health in young children with spina bifida
This project tests a standardized set of urology 'best practices' aimed at protecting kidney function in infants and young children born with spina bifida.
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Pediatric Medical Device Innovation Network (CTIP 3.0)
A national network helps doctors, engineers, and families bring safer and better pediatric medical devices to children.
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MAGIC-PHIV: Microbiome, Gut Inflammation, and Metabolic Health in Youth with Perinatally Acquired HIV
A short, friendly project will study gut health and microbial changes in young people with perinatally acquired HIV to understand links to heart and metabolism as they grow.
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Predicting language outcomes after cochlear implants in children
Aims to use MRI and AI to predict how well kids will develop spoken language after receiving a cochlear implant.
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Digital pathway to support pediatric Down syndrome health care goals
A patient-focused plan to help doctors follow Down syndrome care guidelines for children and make care easier for families.
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Optical Genome Mapping to Improve Diagnosis of Pediatric Brain Tumors
A new test using Optical Genome Mapping could help diagnose brain tumors in children faster and more accurately, guiding better treatment choices.
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Fascin and mitochondria: a new link to Alzheimer’s disease
A study in older adults with Alzheimer’s disease explores how a protein called Fascin may affect mitochondria and brain inflammation to influence the disease.
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How HSV-2 variations affect brain damage in newborns
This project looks at how differences in a common newborn herpes virus may influence brain damage in babies infected around birth.
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Mitochondrial metabolism in brain-inhibitory neurons in kids
Aimed at understanding how mitochondria in brain inhibitory neurons affect a child’s brain function and potentially guide new treatments for mitochondrial-related pediatric conditions.
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Early-onset atrial fibrillation and genetics in kids and young adults
This project looks at why some kids and young adults experience atrial fibrillation early and how their genes might explain recurrence.
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New Biomarkers in Blood to Track Plexiform Neurofibroma Tumor Burden
A study to find blood-based biomarkers that reflect how much plexiform neurofibroma tumors patients with NF1 have, so doctors can monitor tumor burden without relying on frequent MRIs.
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Atlas of Pediatric Acute Care: mapping how emergency care for kids works nationwide
A national effort will map how children receive emergency care across the U.S. to better understand where outcomes differ.
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Immune-driven tubulointerstitial injury in pediatric nephrotic syndrome
A physician-scientist aims to understand how immune processes cause kidney tissue damage in children with difficult-to-treat nephrotic syndrome.
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Pediatric Acute Liver Failure: Quieting the Immune System to Help Young Patients
This grant tests immune-suppressing therapies to help children with acute liver failure by calming an overactive immune response.
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Testing new drugs using patient-derived pediatric brain tumor models
Researchers are using tumor tissue from children with brain tumors to test which drugs may work best.
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Role of human milk components on metabolic health in breastfeeding children of mothers with HIV
A study to understand how breast milk from mothers with HIV and ART exposure may affect the metabolic health and growth of their breastfeeding children.
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Helping childhood cancer survivors and their primary care doctors increase colorectal cancer screening
A remote digital program will help childhood cancer survivors aged 30 and older and their primary care doctors get recommended colorectal cancer screening.
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Why adolescents with obesity often regain weight and how boys and girls differ
This project will look at biological changes that make adolescents with obesity regain weight after losing it, and how those changes differ between sexes.
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Infrastructure to study pediatric elbow and wrist fractures with multicenter trials
A nationwide network is building the framework to test the best way to treat common elbow and wrist fractures in kids, so doctors can base care on solid evidence.
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How stress affects suicidal thoughts and behaviors in Black children with ADHD
This project looks at how stresses from neighborhoods, families, and daily life relate to suicidal thoughts and behaviors in Black children who have ADHD.
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How immune signals and macrophage inflammation affect viral pneumonia in children
Researchers are testing whether lowering a specific immune signal (type I interferon) can reduce harmful lung inflammation in young children with viral pneumonia.
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Lurie Children's–Northwestern neonatal network center
This center runs projects to improve health for newborns—especially preterm or high‑risk babies—and supports their mothers in diverse Chicago communities.
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Soy genistein supplements for infants at risk of asthma
Researchers will give a soy compound called genistein or a placebo to infants who carry a common PAI‑1 gene variant and are at high risk for asthma to try to lower their chance of developing asthma.
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Early infancy hormone patterns and PCOS risk
This project looks at hormone levels during the first months of life in baby girls whose mothers have PCOS to find early signs that might predict later PCOS.
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