MAGIC-PHIV: Microbiome, Gut Inflammation, and Metabolic Health in Youth with Perinatally Acquired HIV
Official title: MAGIC-PHIV: Microbiome and Gut Inflammation in Cardiometabolic Health in Youth with Perinatally Acquired HIV
Funded at Lurie Children's Hospital of Chicago · NIH-11400032 · Data updated 2026-11-12
A short, friendly project will study gut health and microbial changes in young people with perinatally acquired HIV to understand links to heart and metabolism as they grow.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $197,619 |
| NIH project number | 5R21HD118587-02 |
| Project ID | NIH-11400032 on NIH RePORTER |
Who could benefit from this research
✓Could help
YPHIV or adolescents/young adults with perinatally acquired HIV, especially in sub-Saharan Africa and similar settings.
✕Less likely to help
Individuals without HIV or those outside the study regions may not directly benefit.
What this research studies
This project focuses on adolescents and young adults living with perinatally acquired HIV in sub-Saharan Africa and the United States. It uses a multi-omics approach to examine how gut bacteria, inflammation, and metabolic signals interact, aiming to uncover mechanisms behind cardiometabolic risks. Researchers will compare groups with and without HIV exposure, look at gut barrier integrity, and analyze microbiome function to identify potential inflammatory pathways. The study is designed to generate new insights that could guide future interventions to improve long-term health in YPHIV.
Why it matters
Potential benefit: If successful, the work could inform strategies to reduce inflammation and cardiometabolic risk in youths living with HIV.
How similar studies have gone: Prior research shows links between gut microbiota, inflammation, and metabolic health in HIV, but this project aims to expand and specify these findings in YPHIV.
Where this research is happening
-
Lurie Children's Hospital of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Dirajlal-Fargo, Sahera — Lurie Children's Hospital of Chicago
- Study coordinator: Dirajlal-Fargo, Sahera
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.