Early-onset atrial fibrillation and genetics in kids and young adults
Official title: Investigating structural and genetic substrates of early-onset atrial fibrillation
Funded at Lurie Children's Hospital of Chicago · NIH-11364081 · Data updated 2026-11-12
This project looks at why some kids and young adults experience atrial fibrillation early and how their genes might explain recurrence.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $500,051 |
| NIH project number | 5R01HL164773-04 |
| Project ID | NIH-11364081 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and young adults with atrial fibrillation diagnosed at or before age 35 and their families may be eligible to participate.
✕Less likely to help
Patients without early-onset AF or not meeting age criteria may not benefit from this study.
What this research studies
If a young person develops atrial fibrillation before age 35, this research will follow patients across multiple centers to collect clinical data and genetic samples. Using a gene panel, common-variant analysis, and whole-genome sequencing, researchers will explore genetic factors linked to recurrent episodes. The study follows patients over time to see how genetics relate to time to AF recurrence and to guide future care. Located at several pediatric and academic centers, it aims to create evidence to improve treatment decisions for early-onset AF.
Why it matters
Potential benefit: Findings could lead to more personalized treatment strategies and better guidance for families dealing with early-onset AF.
How similar studies have gone: Prior work suggests genetic factors influence AF recurrence, but this project expands the analysis to early-onset cases with comprehensive genomic approaches.
Where this research is happening
-
Lurie Children's Hospital of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Webster, Robert Gregory — Lurie Children's Hospital of Chicago
- Study coordinator: Webster, Robert Gregory
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.