Testing medicines for pediatric brain tumors in mice using patient-derived tumors
Official title: In vivo Drug Testing of Pediatric CNS Tumors Using Patient Derived Orthotopic Xenograft Models
Funded at Lurie Children's Hospital of Chicago · NIH-11537584 · Data updated 2026-11-12
This project tests new drugs for childhood brain tumors in patient-derived mouse models to see which treatments may help kids in the future.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | July 14, 2021 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $310,604 |
| NIH project number | 3U01CA199288-10S2 |
| Project ID | NIH-11537584 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are children with certain pediatric brain tumor subtypes represented in the study models, or samples convertible into patient-derived models for research access.
✕Less likely to help
Children not represented by the tested tumor models or whose tumors do not respond to these drugs may not benefit directly.
What this research studies
Researchers at Lurie Children’s Hospital of Chicago will test several experimental drugs on pediatric brain tumor models created from患者 tumors. They will evaluate how well these drugs shrink tumors and extend survival in vivo, and then explore why some tumors resist treatment. The work builds on a long-running program to identify promising therapies for children with brain cancers. Findings could point toward future clinical trials and better treatment options for young patients.
Why it matters
Potential benefit: If successful, the work could identify drugs that improve survival or quality of life for children with brain tumors and guide future trials.
How similar studies have gone: Previous similar studies using patient-derived models have informed subsequent clinical testing and shown promise in pediatric brain cancers.
Where this research is happening
-
Lurie Children's Hospital of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Li, Xiaonan — Lurie Children's Hospital of Chicago
- Study coordinator: Li, Xiaonan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.