Sponsor or institution
Clinical trials and research at Institute for Systems Biology
As of November 12, 2026, Find a Trial lists 1 clinical trial run by Institute for Systems Biology that is recruiting, in United States. There are also 62 NIH-funded research projects at this institution, with $34.9 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 1Clinical trials
- 62NIH research projects
- 1Country
All recruiting trials (1)
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Markers of Caloric Balance
This project will try to find biological markers that show how calories eaten compare to calories burned in adults.
NIH-funded research (newest 40 of 62)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Digital twin to personalize acute myeloid leukemia treatment
This project builds a virtual copy of an adult's AML using their blood and bone marrow data so doctors can try out treatment options on the model before giving them to the patient.
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Personalized digital models for acute myeloid leukemia
This project creates a computer model of a person's AML from their blood and bone marrow data so doctors and patients can explore which treatments might work best.
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Understanding how Bacteroides fragilis changes affect phage therapy
Researchers will study how a common gut bacterium changes its surface and defense features to evade phages, with the goal of improving phage-based treatments for infections and related diseases.
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AI-powered cancer data hub to map tumor risk and treatment responses
A cancer-focused project will build an AI-driven data platform that combines genomic, transcriptomic, proteomic, and spatial data to better understand cancer risk and how tumors respond to treatment.
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Understanding why some bacteria hide inside cells during infection
A study will look at how a tiny number of Salmonella bacteria inside human cells survive antibiotic treatment by changing both their own genes and the host cell’s gene activity.
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Tissue imaging and spatial profiling resources for tumor studies
A core research resource helps researchers study tumor tissues with advanced imaging and multi-omic profiling to understand their biology.
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Core 1: Mouse Model and Tissue Biobank Core
A research core helps study how immune therapies interact with melanoma treatments using mouse models and human tissue samples, aiming to improve outcomes for kids and others who might benefit in the future.
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Outreach Core for Systems Immuno-Oncology in Melanoma and Solid Tumors
A national outreach program supports patient-facing education and internships while advancing personalized immunotherapy strategies for solid tumors like melanoma.
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Predictive models to guide immunotherapy combinations for melanoma
A study to build and refine computer models that help design better combination immunotherapies for melanoma patients.
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TIME-based immunograms to guide sequential cancer immunotherapy
A patient-friendly look at a research project that tests whether timing and sequencing of immunotherapy with targeted drugs can improve outcomes for people with melanoma and other cancers.
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Administrative Core of a Center for Spatiotemporal Tumor Analytics
A coordinated center is building advanced tools and collaborations to study how to best sequence immunotherapy and targeted therapies for solid tumors like metastatic melanoma.
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Spatiotemporal Tumor Analytics to Guide Sequential Targeted Inhibitors with Immunotherapy
A national team is testing whether giving targeted cancer drugs first and then immunotherapy works better than giving them together, using patient data and animal models to learn the best timing.
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Dfam: smarter, bigger library of repetitive DNA elements to help genomes be understood
A public, open-access database that improves how scientists identify and annotate repetitive DNA elements across many species.
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Understanding how tuberculosis bacteria survive drugs and how to stop them
Aimed at making tuberculosis treatments faster and more effective by studying how the bacteria evade drugs inside the body.
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New tools to capture both familiar and unusual protein chemical tags in bacteria
A research project aims to develop better methods to capture and study both common and non-traditional protein tags in bacteria to understand how they control cell behavior.
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Single-cell gene activity in mixed bacterial communities
A scientist will use a new method to map how individual bacteria in complex communities express genes, helping us understand how these tiny ecosystems work.
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Understanding why frailty differs by sex and how to measure it better
A precision project will explore why women often look more frail than men at the same age but tend to live longer, using AI tools and human data to improve frailty measurements and interventions.
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Personalized gut microbiome model to improve nutrition and health
This project creates personalized computer models of adults' gut microbes, diet, and metabolism to predict how foods and drugs affect their blood and nutrition.
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Understanding Frailty and Aging
This research helps us understand how frailty develops in aging, using advanced tools to predict health changes over time.
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Personalized digital models to predict AML treatment response
This project builds computer-based personalized models to help doctors predict which treatments might work best for adults with acute myeloid leukemia.
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How glioblastoma tumors differ inside the brain and respond to drugs
Mapping how glioblastoma tumor cells differ and change under treatment to find drugs that can kill the treatment-resistant cells in people with glioblastoma.
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Finding rare cancer cells in blood and biopsy samples
This project builds a label-free toolkit to find and analyze extremely rare tumor cells in blood and tissue samples from people with cancer.
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Sequencing immunotherapy and targeted drugs for melanoma
This project tests whether giving immunotherapy first and then a targeted drug, instead of both together, helps people with melanoma respond better.
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Using time-based cancer immunograms to improve immunotherapy treatments
This study is looking at how tracking your immune response over time can help doctors figure out the best combination of immunotherapy treatments for cancer patients, so they can receive more personalized care that works better for them.
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Predicting the best immunotherapy combinations and timing for melanoma
Using smart computer models and detailed tumor data to help choose the best immunotherapy combinations and timing for people with skin melanoma.
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Timing-based immune maps to guide the order of immunotherapy and targeted cancer drugs
This work tests whether a short course of immunotherapy given before targeted cancer drugs helps people with cancers like BRAF‑mutant melanoma respond better.
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Sequencing targeted drugs and immunotherapy to improve cancer treatment
This program develops tools to find the best order and timing of targeted drugs and immunotherapy so people with melanoma and other cancers might get stronger, longer-lasting responses.
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How the immune protein Caspase-1 affects bacteria's resistance to antibiotics
This project looks at whether a human immune protein called Caspase-1 can make bacteria living inside immune cells less resistant to antibiotics, which could help people with hard-to-treat infections.
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Why some small tumors switch from dormancy to active growth
The team looks at whether changes in gene activity in individual cancer cells can signal when a small or dormant tumor is about to start growing, which could help people with early-stage or dormant cancers.
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Understanding placental problems in common pregnancy conditions
This project looks at how the placenta works at a molecular level to better understand common pregnancy conditions like preeclampsia and preterm birth.
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Understanding how individual bacteria behave in communities
This project aims to understand how individual bacteria in complex groups, like those found in the body, behave differently from each other.
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Understanding how early mosquito-stage malaria parasites can help create better vaccines
This study is looking at the early stages of the malaria parasite in mosquitoes to find proteins that could help create vaccines to stop malaria from spreading from humans to mosquitoes, which could be a big step in fighting the disease.
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Using tumor analytics to improve cancer treatment with immunotherapy and targeted inhibitors
This study is looking at a new way to treat cancer by using two types of therapies—targeted inhibitors and immunotherapy—in a specific order to see if it works better, especially for people with melanoma and brain metastases, so that patients can have more effective treatment options.
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Understanding how tuberculosis bacteria resist medicines
This project aims to find new drug combinations that can quickly and completely get rid of tuberculosis bacteria, helping to prevent drug resistance.
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Improving how we find and use immune cells to fight cancer
This research aims to develop better tools to find and understand special immune cells that can specifically target and kill cancer cells.
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Investigating how NLRP3 inflammasome interacts with mitochondrial signaling
This study is looking at a part of your immune system called the NLRP3 inflammasome to see how it reacts to infections and other health issues, with the hope of finding new ways to help people with autoimmune diseases.
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How the immune system influences the behavior of Salmonella bacteria
This study is looking at how our immune system fights off Salmonella infections and how a specific protein from the bacteria helps it spread, with the goal of finding better ways to help our bodies clear the infection.
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Understanding how gut bacteria affect nutrition and health
This study is looking at how the bacteria in your gut affect digestion and health, and it aims to create a personalized tool called 'CyberGut' that helps people understand how their unique gut bacteria and diet work together to influence their health.
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Creating a clock to predict frailty and lifespan in mice
This study is looking at how to predict how long mice will live and how healthy they are by creating a special tool that measures different signs of aging, and it’s especially focused on younger female mice to help us understand aging better, which could also help with human health.
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Improving genome analysis by identifying and annotating repetitive DNA sequences
This study is working on improving how we find and label certain repeating parts of DNA in mammals and other organisms, which is important for understanding their genetic makeup and evolution, and it's designed for scientists who want to make genome studies more accurate and reliable.
Quick answers
How many clinical trials run by Institute for Systems Biology are recruiting right now?
1, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.