Core 1: Mouse Model and Tissue Biobank Core
Funded at Institute for Systems Biology · NIH-11415810 · Data updated 2026-11-12
A research core helps study how immune therapies interact with melanoma treatments using mouse models and human tissue samples, aiming to improve outcomes for kids and others who might benefit in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institute for Systems Biology NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 22, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $416,279 |
| NIH project number | 5U54CA274509-05 |
| Project ID | NIH-11415810 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients or tissue donors with melanoma or related immune-tumor biology could participate through tissue collection and future trials, depending on consent and study design.
✕Less likely to help
Individuals without access to tissue samples or without melanoma-related involvement may not directly benefit.
What this research studies
This grant funds a core that links mouse models and human tumors to study how immune-based and targeted melanoma therapies work together. It will generate multi-scale data on the tumor immune microenvironment and support models that predict response to triplet therapy. The goal is to identify strategies, like prior immune therapy, that could enhance durability and overcome resistance, with a view toward informing future patient care. Researchers will use both animal and human tissue analyses to understand treatment effects over time.
Why it matters
Potential benefit: If successful, the work could guide better combination strategies for immune and targeted therapies in pediatric and adult melanoma patients.
How similar studies have gone: Previous data suggest combining immunotherapy with targeted therapies can be beneficial, but results are mixed and require further refinement.
Where this research is happening
-
Institute for Systems Biology
Seattle, United States Active
Researchers
- Principal investigator: Lo, Roger S — Institute for Systems Biology
- Study coordinator: Lo, Roger S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.