New tools to capture both familiar and unusual protein chemical tags in bacteria
Official title: Interrogation of bacterial pathogen canonical and non-canonical phosphorylation events
Funded at Institute for Systems Biology · NIH-11368830 · Data updated 2026-11-12
A research project aims to develop better methods to capture and study both common and non-traditional protein tags in bacteria to understand how they control cell behavior.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institute for Systems Biology NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | June 12, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $940,934 |
| NIH project number | 1R01AI193322-01A1 |
| Project ID | NIH-11368830 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly; the grant focuses on basic bacterial biology and tool development that could inform future medical research.
✕Less likely to help
Patients are not directly involved in this basic research.
What this research studies
This project builds new reagents called phosphopeptide SuperBinders that selectively grab phosphorylation marks on proteins under gentle conditions, making it easier to study these signals in bacteria. By comparing these new tools to traditional methods, scientists hope to achieve more reliable and comprehensive phosphoprotein profiling. The work involves biochemistry, protein engineering, and mass spectrometry to detect and quantify these modifications. If successful, the approach could reveal new details about bacterial signaling and metabolism that were previously hard to measure.
Why it matters
Potential benefit: Better tools for scientists could lead to deeper understanding of bacterial biology and potentially new angles for antibacterial strategies.
How similar studies have gone: Preliminary work has shown that engineered SH2-domain–based reagents can selectively enrich certain phosphorylation types under mild conditions, suggesting potential for broader application.
Where this research is happening
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Institute for Systems Biology
Seattle, United States Active
Researchers
- Principal investigator: Kusebauch, Ulrike — Institute for Systems Biology
- Study coordinator: Kusebauch, Ulrike
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.