How the immune system influences the behavior of Salmonella bacteria
Official title: Host innate immune mechanisms control temporal expression of flagellin by pathogenic Salmonella
Funded at Institute for Systems Biology · NIH-11086147 · Data updated 2026-11-12
This study is looking at how our immune system fights off Salmonella infections and how a specific protein from the bacteria helps it spread, with the goal of finding better ways to help our bodies clear the infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institute for Systems Biology NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | June 10, 2021 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $490,327 |
| NIH project number | 5R01AI155685-05 |
| Project ID | NIH-11086147 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with Salmonella infections or are at high risk for such infections.
✕Less likely to help
Patients with infections caused by non-Salmonella pathogens or those who do not have an active infection may not benefit from this research.
What this research studies
This research investigates how the immune system's inflammasomes detect and respond to Salmonella infections. It focuses on the interaction between the host's immune response and the expression of a bacterial protein called flagellin, which plays a role in the bacteria's ability to spread and evade the immune system. By understanding this interaction, the research aims to uncover mechanisms that could enhance the clearance of Salmonella from the body. The approach involves studying the signaling pathways and feedback loops that regulate this process.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating infections caused by Salmonella and potentially other bacterial pathogens.
How similar studies have gone: Previous research has shown success in understanding inflammasome mechanisms in other bacterial infections, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Institute for Systems Biology
Seattle, United States Active
Researchers
- Principal investigator: Subramanian, Naeha — Institute for Systems Biology
- Study coordinator: Subramanian, Naeha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.