How the immune system influences the behavior of Salmonella bacteria
Host innate immune mechanisms control temporal expression of flagellin by pathogenic Salmonella
['FUNDING_R01'] · INSTITUTE FOR SYSTEMS BIOLOGY · NIH-11086147
This study is looking at how our immune system fights off Salmonella infections and how a specific protein from the bacteria helps it spread, with the goal of finding better ways to help our bodies clear the infection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INSTITUTE FOR SYSTEMS BIOLOGY (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11086147 on ClinicalTrials.gov |
What this research studies
This research investigates how the immune system's inflammasomes detect and respond to Salmonella infections. It focuses on the interaction between the host's immune response and the expression of a bacterial protein called flagellin, which plays a role in the bacteria's ability to spread and evade the immune system. By understanding this interaction, the research aims to uncover mechanisms that could enhance the clearance of Salmonella from the body. The approach involves studying the signaling pathways and feedback loops that regulate this process.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with Salmonella infections or are at high risk for such infections.
Not a fit: Patients with infections caused by non-Salmonella pathogens or those who do not have an active infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating infections caused by Salmonella and potentially other bacterial pathogens.
How similar studies have performed: Previous research has shown success in understanding inflammasome mechanisms in other bacterial infections, suggesting that this approach may yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- INSTITUTE FOR SYSTEMS BIOLOGY — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUBRAMANIAN, NAEHA — INSTITUTE FOR SYSTEMS BIOLOGY
- Study coordinator: SUBRAMANIAN, NAEHA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.