Understanding Frailty and Aging
Official title: Development of a Predictive Frailty Clock & Longitudinal Investigation of its Epigenetic Determinants
Funded at Institute for Systems Biology · NIH-11322958 · Data updated 2026-11-12
This research helps us understand how frailty develops in aging, using advanced tools to predict health changes over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institute for Systems Biology NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2021 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $131,600 |
| NIH project number | 3R00AG070102-05S1 |
| Project ID | NIH-11322958 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is relevant to anyone interested in understanding the aging process and preventing age-related frailty.
✕Less likely to help
Patients seeking immediate clinical interventions or direct treatment options will not find direct benefit from this basic science project.
What this research studies
This project aims to create a "frailty clock" that can predict how long an individual might live and track their overall health as they age. While the initial work is done in mice, the insights gained are directly relevant to human aging and frailty. By looking at various health measures, including blood samples, we hope to identify early signs of frailty and understand its underlying biological causes. This could eventually lead to better ways to keep people healthier for longer.
Why it matters
Potential benefit: If successful, this work could lead to new ways to predict and potentially prevent frailty in people, helping them maintain their health and independence as they age.
How similar studies have gone: Previous work has successfully validated a mouse frailty index and used machine learning to predict lifespan, building a strong foundation for this project.
Where this research is happening
-
Institute for Systems Biology
Seattle, United States Active
Researchers
- Principal investigator: Kane, Alice E — Institute for Systems Biology
- Study coordinator: Kane, Alice E
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Functioning, Frailty, and Well-being in aging women
A large NIH grant is funding a study to understand how aging affects physical and mental functioning in women, with the goal of helping maintain independence and quality of life.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.