Investigating how NLRP3 inflammasome interacts with mitochondrial signaling
Official title: NLRP3 inflammasome activation and its crosstalk with RLR signaling at the mitochondria
Funded at Institute for Systems Biology · NIH-11088898 · Data updated 2026-11-12
This study is looking at a part of your immune system called the NLRP3 inflammasome to see how it reacts to infections and other health issues, with the hope of finding new ways to help people with autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institute for Systems Biology NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | June 15, 2021 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $470,000 |
| NIH project number | 5R01AI163131-05 |
| Project ID | NIH-11088898 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from autoimmune or autoinflammatory conditions.
✕Less likely to help
Patients with non-autoimmune related conditions may not receive any benefit from this research.
What this research studies
This research focuses on understanding the NLRP3 inflammasome, a key component of the immune system that responds to infections and metabolic issues. It explores how NLRP3 detects various stimuli and assembles a signaling complex that activates important cytokines involved in autoimmune and autoinflammatory diseases. By examining the interaction between NLRP3 and mitochondria, the research aims to uncover new mechanisms that could influence immune responses and disease progression. Patients may benefit from insights that could lead to novel treatments for conditions linked to NLRP3 activation.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating autoimmune and autoinflammatory diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammasomes in immune responses, suggesting that this approach could yield significant insights.
Where this research is happening
-
Institute for Systems Biology
Seattle, United States Active
Researchers
- Principal investigator: Subramanian, Naeha — Institute for Systems Biology
- Study coordinator: Subramanian, Naeha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.