Personalized digital models for acute myeloid leukemia
Official title: Prototype System for AML Digital Twins
Funded at Institute for Systems Biology · NIH-11492233 · Data updated 2026-11-12
This project creates a computer model of a person's AML from their blood and bone marrow data so doctors and patients can explore which treatments might work best.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institute for Systems Biology NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $72,373 |
| NIH project number | 3R01CA270210-04S1 |
| Project ID | NIH-11492233 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 and older with acute myeloid leukemia who can provide clinical data plus blood and bone marrow specimens, including patients with relapsed or refractory disease.
✕Less likely to help
People without AML, those unable or unwilling to give required samples, or patients needing immediate emergency therapy are unlikely to benefit from this prototype.
What this research studies
If I had AML, researchers would build a computer 'digital twin' of my leukemia using my clinical records, blood tests, and a bone marrow sample. The model combines clinical and molecular data to simulate how my disease might respond to different drugs. Doctors could use an interactive tool with me to compare predicted outcomes of treatment options without trying them on my body first. The team at the Institute for Systems Biology is creating a prototype system that would require sharing samples and health data with the research group.
Why it matters
Potential benefit: Could help tailor treatment choices by predicting which therapies are most likely to work for an individual patient's AML.
How similar studies have gone: Digital twin methods have shown early promise in other medical areas, but applying them to AML is largely new and still experimental.
Where this research is happening
-
Institute for Systems Biology
Seattle, United States Active
Researchers
- Principal investigator: Thorsson, Vesteinn — Institute for Systems Biology
- Study coordinator: Thorsson, Vesteinn
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Digital twin to personalize acute myeloid leukemia treatment
This project builds a virtual copy of an adult's AML using their blood and bone marrow data so doctors can try out treatment options on the model before giving them to the patient.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.