Understanding placental problems in common pregnancy conditions
Official title: Enhancing insight into placental dysfunction in common obstetric disorders using placental multiomics
Funded at Institute for Systems Biology · NIH-11136415 · Data updated 2026-11-12
This project looks at how the placenta works at a molecular level to better understand common pregnancy conditions like preeclampsia and preterm birth.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institute for Systems Biology NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 11, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $246,885 |
| NIH project number | 5R21HD112819-02 |
| Project ID | NIH-11136415 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research uses existing de-identified data from people who have experienced various singleton pregnancies, including those with preeclampsia, preterm birth, or fetal growth restriction.
✕Less likely to help
Patients not experiencing or at risk for preeclampsia, preterm birth, or fetal growth restriction may not directly benefit from this specific research.
What this research studies
Many pregnancy conditions, such as preeclampsia, preterm birth, and fetal growth restriction, are common but complex. We know that problems with the placenta play a role in these conditions, but we don't fully understand the tiny molecular changes happening. This work uses advanced techniques to look at many different molecular details from placental samples. By studying these details, we hope to uncover the specific ways placental issues contribute to these pregnancy challenges.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify, prevent, or treat serious pregnancy complications by revealing their root causes in the placenta.
How similar studies have gone: Integrated multiomic analysis is a cutting-edge approach, and while individual 'omic' studies have shown promise, combining them for placental dysfunction in this way is a novel and comprehensive approach.
Where this research is happening
-
Institute for Systems Biology
Seattle, United States Active
Researchers
- Principal investigator: Hadlock, Jennifer — Institute for Systems Biology
- Study coordinator: Hadlock, Jennifer
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.