Sponsor or institution
Clinical trials and research at Cincinnati Childrens Hosp Med Ctr
As of November 12, 2026, Find a Trial lists 639 NIH-funded research projects at this institution, with $377.6 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 639NIH research projects
NIH-funded research (newest 40 of 639)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Accelerating Rheumatic Heart Disease Prevention in Uganda
A program to find people with rheumatic heart disease in Ugandan communities and give them preventive care close to home.
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Enhanced surveillance network to track childhood vaccines and viral infections in kids
A nationwide pediatric surveillance network will closely watch how common viruses and vaccines affect children’s health, using standard protocols at hospital and ED sites.
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Advancing CNS drug delivery through epigenetic tweaks
A medical research project aims to help people with lysosomal storage disorders by improving how treatments reach the brain.
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Spina Bifida Registry for Better Clinic Care
A national registry project aims to improve care for people with spina bifida by collecting and sharing data from multidisciplinary clinics to guide evidence-based practices.
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Hydroxyurea to help children with sickle cell anemia in Africa
A pediatric study tests hydroxyurea treatment for young children with sickle cell anemia in several African countries to see if it can reduce illness and improve health.
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Hydroxyurea for Children with Sickle Cell in Africa
A pilot study tests hydroxyurea in young children with sickle cell disease across several African countries to see if it can reduce illness and hospital visits.
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Hydroxyurea for Children with Sickle Cell Disease in Africa
A safe and feasible use of hydroxyurea for young children with sickle cell disease in several African countries to reduce illness and improve daily life.
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Antibiotics, gut health, and skin reactions in kids
A small study in children will look at whether antibiotic use and gut bacteria play a role in hives and related symptoms that children sometimes get after antibiotics.
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Frequent Exacerbator Pediatric Asthma: A Multi-Omics Approach
A pediatric multi-omics study aims to understand why some children with asthma have more frequent flare-ups and how that affects their health and care.
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Mobile hearing care delivered by community health workers with smart devices
A smartphone-enabled program lets trained community health workers test hearing, fit devices, and support users in low-resource communities, aiming to improve access to hearing care.
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Data Management and Coordinating Center support for Rare Diseases Research
A national rare diseases research program is funding a center to manage data and coordinate studies to help improve diagnosis, care, and potential treatments for children with rare conditions.
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Pan-Filovirus VLP vaccine that targets multiple Ebola-like viruses
A new vaccine approach using virus-like particles aims to protect against several dangerous filoviruses, including Bundibugyo and Sudan viruses, in Africa.
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Sirolimus to Prevent Epilepsy in Infants with Tuberous Sclerosis Complex (TSC)
A groundbreaking study tests whether giving sirolimus early to babies with TSC can prevent or delay seizures.
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How HIV-1 moves into macrophages and spreads via a special cell pathway
Researchers are studying how HIV-1 particles are captured by macrophages and transmitted to other cells using a specific cell-entry route called the CLIC/GEEC pathway.
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Xenbase: a knowledgebase for the Xenopus model organism
A comprehensive online resource that organizes Xenopus research data to help scientists connect findings to human health.
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Remote monitoring of Alzheimer’s changes in adults with Down syndrome
A study tests remote (at-home) ways to track Alzheimer’s-related thinking changes in adults with Down syndrome.
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Hematology Co-Excellence Center at Cincinnati Children’s Hospital
A multi-center program in Cincinnati aims to uncover how blood-forming stem cells behave and how to fix blood diseases at the molecular level.
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Understanding how daily rhythms and sensory signals wire the brain’s clocks
A lab grant to upgrade a mouse study with real-time brain activity recordings to learn how circadian timing and senses are integrated in brain circuits.
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Visualizing how morphogens shape fetal development in human cells
Researchers are studying how key signaling proteins guide early human development using labeled Nodal in stem cells to visualize patterns as cells organize themselves.
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HBCD PRELUDE: Understanding How Early Life Experiences Shape Brain Development
This grant supports a large study of how prenatal and early-life experiences affect a child’s brain and development over the first 10 years.
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Genetic risk scoring to guide health in families
A national effort uses genetic risk scores and medical records to understand how DNA-based risk information affects health actions for both kids and adults.
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How signals shape early skin and nervous system development
Using human stem-cell models, this project looks at how cell signals guide the formation and folding of early nervous system and skin tissues to help people affected by neural tube and related birth defects.
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Macrophages and testosterone: how immune cells support adult testicular function
This grant looks at how specific immune cells in the testicles help adult men make testosterone and what that means for treating low testosterone.
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Monthly penicillin injections versus daily oral penicillin to prevent early rheumatic heart disease from getting worse
This trial compares daily oral penicillin to monthly penicillin shots for children with early, hidden rheumatic heart disease.
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Monthly penicillin injections versus daily oral penicillin to prevent early rheumatic heart disease
This compares monthly penicillin shots with daily oral penicillin for children who have early (latent) rheumatic heart disease to prevent the condition from getting worse.
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Monthly injections versus daily oral penicillin to stop early rheumatic heart disease from getting worse
This trial compares daily oral penicillin to monthly injections to see if the easier oral option can prevent early rheumatic heart disease from worsening in children.
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Clinical Upgrade: New options for eosinophilic GI diseases
A new NIH grant tests targeted therapies for people with eosinophilic gastrointestinal diseases beyond the esophagus, aiming to improve symptoms and disease signs.
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OMEGA: Understanding Eosinophilic GI Diseases in Children
A pediatric-focused effort to better understand eosinophilic gastritis, enteritis, and colitis in kids and to find biomarkers and patient-friendly outcomes.
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Pilot and Feasibility program to advance eosinophilic gastrointestinal diseases
A nationwide group is piloting quick, small studies to improve diagnosis and treatment of eosinophilic gastritis, enteritis, and colitis in children and adults.
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Consortium improving care for eosinophilic gastrointestinal diseases
A network of clinics is working together to advance care for adults with rare eosinophilic gut diseases like eosinophilic gastritis, enteritis, and colitis, with patient needs and trial readiness at the forefront.
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Helping lungs heal after tuberculosis by clearing infected cells
Using a cancer drug that helps infected cells die alongside antibiotics to help people with lung tuberculosis recover faster and reduce long-term lung damage.
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Pseudovirus Nanoparticle–Based Mpox Vaccine for Oral Immunization
A new oral mpox vaccine using pseudovirus nanoparticles to display mpox antigens and stimulate mucosal immunity.
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Sleep and vaccines in teens: can better sleep boost their vaccine response
A small study will test whether improving sleep in healthy 11–12 year-olds can boost their vaccine immune response.
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SURFS-UP: Understanding Phenotypes in Syndrome of Undifferentiated Recurrent Fevers
This project aims to map the varied immune profiles of people with recurrent fevers to find distinct biological patterns that could guide better treatments.
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Non-canonical BRAF mutations and AML treatment response
This project looks at how unusual BRAF gene mutations affect how acute myeloid leukemia behaves and responds to therapy.
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Pathogenesis and Treatment of Kaposiform Lymphangiomatosis
Aims to understand what drives a rare childhood disease, Kaposiform lymphangiomatosis (KLA), and to improve its diagnosis and treatment so affected children and young adults can live longer and healthier lives.
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Compact CRISPR-based activation to target lung vascular enhancers in a mouse model
A tiny CRISPR-based gene-activation system delivered by AAV aims to turn on specific lung gene enhancers to treat alveolar capillary dysplasia and related lung conditions in a mouse model.
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Riboregulation of Innate Immune Signaling
A funded project will explore how RNA molecules help control the body's initial immune defenses and how this could influence autoimmune diseases and cancers.
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Nuclear rupture and repair in LMNA-related cardiomyopathy
A study to understand how defects in the nuclear envelope cause a dangerous heart disease and to test new ways to repair it.
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How blood-making cells are controlled in the bone marrow
Researchers are studying how different early blood cells, not just stem cells, contribute to everyday blood production and how immune signals influence them.
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