Frequent Exacerbator Pediatric Asthma: A Multi-Omics Approach
Official title: Multi-omics of the Frequent Exacerbator Asthmatic
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11598481 · Data updated 2026-11-12
A pediatric multi-omics study aims to understand why some children with asthma have more frequent flare-ups and how that affects their health and care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | April 9, 2021 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $328,646 |
| NIH project number | 3U01AI159087-06S1 |
| Project ID | NIH-11598481 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and youths with asthma (including those from urban, low-income backgrounds) who experience frequent exacerbations may be eligible.
✕Less likely to help
Children with well-controlled asthma and infrequent exacerbations may have less direct benefit from this specific study.
What this research studies
This project focuses on children with asthma who experience two or more exacerbations per year and uses advanced omics methods to uncover biological and clinical factors associated with these frequent flares. Researchers will collect and integrate biological samples, clinical data, and environmental information to identify patterns linked to increased risk. The goal is to inform better risk stratification, personalized management, and targeted interventions for high-risk pediatric patients in urban settings. Parents and caregivers may be engaged to support study activities and help translate findings into real-world care improvements.
Why it matters
Potential benefit: This research could lead to earlier identification of high-risk children and more effective, personalized treatments to reduce asthma flare-ups and healthcare costs.
How similar studies have gone: Prior studies have begun to identify phenotypes related to frequent exacerbations, but this project aims to deepen understanding with a multi-omics approach.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Khurana Hershey, Gurjit K. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Khurana Hershey, Gurjit K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.