SURFS-UP: Understanding Phenotypes in Syndrome of Undifferentiated Recurrent Fevers
Official title: Syndrome of Undifferentiated Recurrent Fevers: Understanding Phenotypes (SURFs-UP)
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11450296 · Data updated 2026-11-12
This project aims to map the varied immune profiles of people with recurrent fevers to find distinct biological patterns that could guide better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 22, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $758,906 |
| NIH project number | 1R01AI195886-01A1 |
| Project ID | NIH-11450296 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with suspected SURF across a wide age range, including children and adults, who are part of the established SURF cohort and experiencing or at risk of fever flares.
✕Less likely to help
People without SURF or without fever flares or relevant genetic markers may not benefit from this study.
What this research studies
Researchers will study people with Syndrome of Undifferentiated Recurrent Fevers to identify specific immune and genetic features that appear during fever flares. Using single-cell genomics on blood samples from a well-characterized SURF cohort, they will define proinflammatory transcriptional phenotypes and link them to genetic variants. The goal is to characterize distinct SURF subtypes to inform future targeted therapies and improve quality of life for patients across ages.
Why it matters
Potential benefit: If successful, this work could lead to more precise diagnoses and personalized treatments for people with SURF.
How similar studies have gone: Previous research has shown that single-cell genomics can reveal distinct inflammatory patterns in complex fevers, supporting the potential for meaningful subtype discovery in SURF.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Schulert, Grant Sanford — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Schulert, Grant Sanford
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.