Clinical Upgrade: New options for eosinophilic GI diseases
Official title: Clinical Trial 2: UPGRADE
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11464394 · Data updated 2026-11-12
A new NIH grant tests targeted therapies for people with eosinophilic gastrointestinal diseases beyond the esophagus, aiming to improve symptoms and disease signs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 15, 2014 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $612,444 |
| NIH project number | 2U54AI117804-11 |
| Project ID | NIH-11464394 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21+ with eosinophilic gastritis, eosinophilic duodenitis or related EGID, who meet specific health criteria and consent to participate.
✕Less likely to help
Some participants may not experience symptom relief or may encounter treatment-related side effects.
What this research studies
This project focuses on eosinophilic gastritis and eosinophilic duodenitis, conditions with rising impact and limited approved treatments. It builds on prior findings that type 2 immune pathways contribute to EGID and explores new therapeutic approaches beyond current diets and topical steroids. The study combines cellular, molecular, and genetic methods across multiple sites to identify effective strategies and associated biomarkers that could guide future care. If successful, it could lead to more precise treatments that reduce symptoms and tissue inflammation for adults with these conditions.
Why it matters
Potential benefit: If successful, patients could gain more targeted and effective treatment options for non-EoE EGID.
How similar studies have gone: Previous studies showed improvement with targeted therapy, but complete remission was uncommon, indicating a need for additional approaches.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Rothenberg, Marc E. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Rothenberg, Marc E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.