Pseudovirus Nanoparticle–Based Mpox Vaccine for Oral Immunization
Official title: A Pseudovirus Nanoparticle-Based Mpox Vaccine for Oral Immunization
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11451690 · Data updated 2026-11-12
A new oral mpox vaccine using pseudovirus nanoparticles to display mpox antigens and stimulate mucosal immunity.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 1, 2026 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $243,000 |
| NIH project number | 1R21AI193189-01A1 |
| Project ID | NIH-11451690 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals at risk for mpox exposure who could benefit from a non-injectable vaccine.
✕Less likely to help
People with mpox infection at enrollment or certain immune-compromised individuals may not benefit from this early-stage approach.
What this research studies
This project uses a novel oral vaccine platform that presents mpox antigens on harmless nanoparticle shells to trigger protective antibodies through the gut. The vaccine includes an adjuvant that helps antigens endure the digestive tract and boost mucosal immune responses. If successful, the approach could lead to a safe, easier-to-administer mpox vaccine that reduces infection and transmission.
Why it matters
Potential benefit: If successful, this vaccine could provide a safer, easier option for preventing mpox infection through oral administration.
How similar studies have gone: Previous nanoparticle vaccines have shown promise in preclinical models, supporting exploration of this platform.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Tan, Ming — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Tan, Ming
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.