Pan-Filovirus VLP vaccine that targets multiple Ebola-like viruses
Official title: Evaluation of a pan-Filovirus virus-like particle (VLP) vaccine.
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11572340 · Data updated 2026-11-12
A new vaccine approach using virus-like particles aims to protect against several dangerous filoviruses, including Bundibugyo and Sudan viruses, in Africa.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $808,811 |
| NIH project number | 1R56AI192635-01A1 |
| Project ID | NIH-11572340 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable for this preclinical grant; future trials would involve people at risk of filovirus exposure or healthcare workers in outbreak settings.
✕Less likely to help
No direct patient participation in this preclinical study.
What this research studies
This grant supports testing a bivalent virus-like particle vaccine that presents glycoproteins from multiple filoviruses to build broad immunity. Researchers will use animal models and immunology techniques to measure antibody and T-cell responses, along with safety assessments. The project builds on prior non-human primate data suggesting cross-protection with multi-virus GP components, moving toward a vaccine that could prevent outbreaks caused by different filoviruses. Results could guide future human studies and vaccine design for broader outbreak readiness.
Why it matters
Potential benefit: If successful, the vaccine could provide broader protection against multiple filoviruses in at-risk populations in Africa.
How similar studies have gone: Preclinical work with multi-virus GP VLPs has shown strong immune responses and cross-reactivity in animal models.
Where this research is happening
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Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Singh, Karnail — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Singh, Karnail
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.