Genetic risk scoring to guide health in families
Official title: Polygenic and Integrated Genomic Risk Assessment for Healthier U.S. Families
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11512334 · Data updated 2026-11-12
A national effort uses genetic risk scores and medical records to understand how DNA-based risk information affects health actions for both kids and adults.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 1, 2020 |
| Project end | April 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $438,114 |
| NIH project number | 3U01HG011172-05S2 |
| Project ID | NIH-11512334 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are children and adults whose medical records are part of the eMERGE network and who may receive or have received genome-informed risk results.
✕Less likely to help
Individuals not receiving genome-informed results or not engaged in follow-up care may see limited benefit.
What this research studies
This project looks at how genomic risk information, gathered from DNA samples linked to electronic health records, can influence medical decisions for 5,000 children and 20,000 adults. It tests what happens when people learn their genome-based risk for common diseases and how clinicians and families respond in the following months. The study builds on prior eMERGE work, returning results to participants and tracking health actions that occur after risk information is shared. Cincinnati Children’s Hospital has actively contributed by enrolling participants, returning results, surveying providers, and reconsenting pediatric participants as they turn 18. The goal is to learn whether returning genome-informed risk data leads to meaningful changes in care and health outcomes.
Why it matters
Potential benefit: If successful, the study could clarify how genomic risk information can be used to personalize care and prevent disease in families.
How similar studies have gone: Previous eMERGE work has shown that returning genomic results can be implemented in healthcare systems and yields measurable clinical actions.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Kottyan, Leah Claire — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Kottyan, Leah Claire
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.