Riboregulation of Innate Immune Signaling
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11430394 · Data updated 2026-11-12
A funded project will explore how RNA molecules help control the body's initial immune defenses and how this could influence autoimmune diseases and cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $486,000 |
| NIH project number | 1DP2AI200954-01 |
| Project ID | NIH-11430394 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals with autoimmune conditions or certain B-cell cancers who might benefit from therapies targeting RNA-mediated immune regulation in the future.
✕Less likely to help
Patients without autoimmune disease or B-cell malignancies may have indirect relevance unless related biomarkers or therapies emerge from this work.
What this research studies
This project examines how RNA interacts with key immune signaling complexes to regulate responses that protect against infections while avoiding excessive inflammation. Researchers will study the myddosome and CBM signalosome to understand RNA's role as a regulator and scaffold within these complexes. New methods will be developed to map RNA–protein interactions in these signaling hubs and to test how riboregulation affects disease-relevant immune activity. The work aims to reveal molecular details that could inform new strategies for treating autoimmune diseases and certain cancers.
Why it matters
Potential benefit: Understanding riboregulation could lead to novel approaches to modulate immune signaling in autoimmune diseases and cancer.
How similar studies have gone: Prior research has shown that RNA can influence protein complexes, suggesting potential for this approach, though direct clinical translation remains early-stage.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Gokhale, Nandan Satish — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Gokhale, Nandan Satish
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.