How blood-making cells are controlled in the bone marrow
Official title: Regulation of long-lasting hematopoietic multipotent progenitors
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11425818 · Data updated 2026-11-12
Researchers are studying how different early blood cells, not just stem cells, contribute to everyday blood production and how immune signals influence them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $715,504 |
| NIH project number | 1R01HL187582-01 |
| Project ID | NIH-11425818 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with blood diseases or bone marrow disorders who have issues with blood cell production may eventually benefit from advances informed by this research.
✕Less likely to help
This basic science work may not directly benefit individuals in the short term or without related clinical translation.
What this research studies
This project looks at how hematopoietic progenitors work alongside stem cells to maintain blood cell production. It focuses on a special, quiet subset of multipotential progenitors that act like stem cells under certain conditions and how MHC class II and bone marrow T cells regulate them. The study uses lab analyses to understand how these cells respond to inflammation and stress, with potential insights into steady-state blood maintenance. The findings could reveal new targets for improving bone marrow function in diseases of the blood.
Why it matters
Potential benefit: If successful, the work may lead to new approaches for supporting healthy blood production in patients with bone marrow disorders.
How similar studies have gone: Preliminary data suggest that progenitor cells can play a larger role in blood production, indicating potential for meaningful progress with similar approaches.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Reynaud, Damien — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Reynaud, Damien
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.