Sponsor or institution
Clinical trials and research at Children's Mercy Hosp (Kansas City, Mo)
As of November 12, 2026, Find a Trial lists 71 NIH-funded research projects at this institution, with $30.9 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 71NIH research projects
NIH-funded research (newest 40 of 71)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Optimal dosing of brain drugs for children
This project aims to figure out the best doses for medicines that affect the brain in kids, by studying how much drug reaches the brain and using non-invasive ways to measure it.
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Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
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Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
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CKiD Cardiovascular Testing Travel Supplement
A funding opportunity to help adolescents and young adults with CKD travel to sites where important heart and blood-vessel tests can be done, with a parent accompanying them.
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Unraveling genetic causes of unsolved pediatric leukodystrophy with HiFi long-read sequencing
A pediatric-focused study tests how advanced long-read genome sequencing can find hidden genetic causes in kids with leukodystrophy who were not diagnosed using standard tests.
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Early sugar exposure in infancy and how it affects glucose and obesity risk
This project follows babies from age 3 months to 12 months to see if higher added sugars in formula and early foods lead to more variable blood sugar and faster weight gain.
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Standardizing Antibiotic Prescribing for Children with Infections using New Metrics and Clinical Decision Tools
A clinician-focused grant aims to improve how antibiotics are prescribed to hospitalized children by using new measures and an electronic decision support tool.
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Understanding how state income support affects pediatric hospitalizations and child maltreatment
This project looks at how different state policies that provide income support to families influence hospital stays for kids and rates of child maltreatment.
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Early sympathetic nerve development and infant neuroblastoma
This project looks at how embryonic nerve cells grow and connect to help explain causes of infant neuroblastoma and some birth defects.
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Bioinformatics Core for Plasma Cell Dyscrasias
A research project at Children’s Mercy Hospital will use advanced genetic analysis to study MGUS, multiple myeloma, and Waldenström’s macroglobulinemia by examining tumor cells and bone marrow samples over time.
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Prevent IgM MGUS from progressing by targeting the driver mutation
A patient-facing program aims to stop progression of IgM MGUS to serious blood cancers by attacking a key cancer-causing mutation with AI-guided drug discovery.
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Preventing MGUS from Becoming Multiple Myeloma by Changing the Bone Marrow Environment
A study in mice and human samples aims to slow or stop MGUS from turning into multiple myeloma by altering the bone marrow surroundings.
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Administrative Core for CAP-MGUS Center
A central administrative program supports a nationwide effort to prevent progression from MGUS (a blood condition) to cancer by coordinating bioinformatics, research projects, and outreach.
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Cancer prevention against MGUS progression
A nationwide center is being created to stop MGUS from turning into blood cancers by identifying targets and using precision prevention strategies.
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Chronic Kidney Disease in Children: following kids as they grow into young adults
A long-running study will keep tracking children with kidney disease and enroll teens to learn how kidney function changes as they reach young adulthood, using home data collection and online reporting.
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DNA repair problems in men with no sperm and higher cancer risk
This project looks at whether men who have no sperm because their testes can't make it have problems fixing DNA that could raise their chance of some cancers.
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Mapping genetic clues of rare childhood diseases
A researcher team at Children’s Mercy is building better ways to understand how genetic differences cause rare diseases in kids by looking beyond simple gene changes.
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Finding genetic causes of unexplained childhood leukodystrophies with advanced long-read genome sequencing
Using AI and more complete long-read genome sequencing to find hidden genetic causes in children with unexplained leukodystrophy.
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Chronic kidney disease in children and young adults
Following children and teens with chronic kidney disease over time to track how their kidney function and heart health change and what factors speed decline.
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Tracking kidney health from childhood into young adulthood
This project follows children and teens with chronic kidney disease to learn how kidney function and heart health change as they grow into young adults.
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Unraveling genetic causes of unsolved pediatric leukodystrophy with long-read genomes
A study using advanced long-read genome sequencing and AI tools to find hidden genetic causes of leukodystrophies in children who remain undiagnosed after standard tests.
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Understanding the ethics of epigenetic prenatal testing and how it affects families and clinicians
This grant would explore how epigenetic signals from a mother’s blood in prenatal testing could influence decisions, privacy, and care for pregnant people and babies.
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Finding biomarkers and causes of dangerous antibiotic reactions
This project aims to find biological signs that show who is at risk for severe, life-threatening reactions to the common antibiotic trimethoprim-sulfamethoxazole (TMP-SMX).
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5-base HiFi sequencing to uncover genetic roots of pregnancy loss
A comprehensive genomic resource will look for inherited or new genetic changes that explain unexplained pregnancy loss, by studying trios (child and both parents) and using advanced long-read DNA sequencing.
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Mapping the immune landscape of ovarian tumors to predict outcomes
This project uses advanced tumor imaging and new statistical models to map immune cells in ovarian tumors and help predict survival for women with ovarian cancer.
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DLL4 and newborn lung development in bronchopulmonary dysplasia
This work looks at whether restoring a protein called DLL4 can help blood vessel and air sac growth in premature babies with bronchopulmonary dysplasia (BPD).
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Killing p53-deficient cancers by boosting harmful oxygen and blocking DNA repair
New drugs that raise damaging oxygen levels and block DNA repair are being developed to kill cancers that lack a working p53 gene.
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Helping families overcome social barriers to support healthy weight in children
This pilot will see whether community health workers who connect families to social supports help children in family-based weight programs do better.
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SIGIRR and newborn gut barrier health
This project focuses on how changes in the SIGIRR gene weaken gut defenses in preterm babies who are at risk for necrotizing enterocolitis (NEC).
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Pinpointing genetic causes of congenital birth defects
Using children's genetic data, lab-grown mini-organs, and zebrafish tests to find genetic changes that cause congenital birth defects.
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Finding Genetic Answers for Children with Leukodystrophy
This project uses advanced genetic testing and artificial intelligence to find the missing genetic causes for children with leukodystrophy whose condition hasn't been fully explained yet.
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How placental cells that remodel maternal blood vessels develop
This project looks at how a gene called ASCL2 helps the placental cells that reshape a mother's arteries during pregnancy grow and function to support a healthy pregnancy.
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Personalized CT and airflow modeling to detect upper airway blockage in infants
It creates personalized 3D CT scans combined with computer airflow models to better measure airway blockage in babies with Robin Sequence and similar conditions.
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An inhaled medicine for tiny babies' lungs
This research is exploring a new inhaled medicine called ciclesonide to help protect the lungs of very premature babies.
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Finding genetic causes of complex childhood rare diseases
This work tries to find how complex genetic changes cause rare childhood diseases so that more children with undiagnosed conditions can get clearer answers.
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Understanding genetic causes of pregnancy loss
This study is looking at the genetic reasons behind unexplained pregnancy losses by examining DNA from both parents and the babies that didn't make it, and it's designed for families who have experienced recurrent pregnancy loss to help us learn more about what might be causing it.
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Monitoring stomach and breathing viruses in children
This program watches how often children get diarrheal and respiratory infections and checks how well vaccines protect them.
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Long-term tracking of kidney and heart health in children and teens with chronic kidney disease
Tracking children and teens with chronic kidney disease to learn how kidney function and heart health change as they grow into young adults.
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Creating a biomarker to understand how opioid antagonists work in adolescents with eating disorders
This study is looking to find a way to better understand how certain medications can help teenagers with eating disorders like Anorexia Nervosa and Binge Eating Disorder, so we can improve their treatment options.
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Investigating the immune environment of ovarian cancer tumors to improve survival predictions for patients
This study is looking at how immune cells behave in ovarian cancer tumors to help doctors understand how they affect the disease and improve treatment options for women with ovarian cancer.
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