NIH-funded research R01 grant

Early sugar exposure in infancy and how it affects glucose and obesity risk

Official title: First taste, lasting impact: Early-life exposure to added sugars from infant formula and complementary foods on glucose variability and obesity risk.

Funded at Children's Mercy Hosp (Kansas City, Mo) · NIH-11429651 · Data updated 2026-11-12

This project follows babies from age 3 months to 12 months to see if higher added sugars in formula and early foods lead to more variable blood sugar and faster weight gain.

More Obesity research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionChildren's Mercy Hosp (Kansas City, Mo)
NIH-funded
Lab location1 site (Kansas City, United States)
Project startAugust 28, 2026
Project endJune 30, 2031
Funding year2026
Award (this year)$532,087
NIH project number1R01DK149491-01
Project IDNIH-11429651 on NIH RePORTER

Who could benefit from this research

Could help

Infants around 3 months old whose parents consent to participate and who are otherwise healthy.

Less likely to help

Infants with significant health issues or families unable to comply with CGM wear may not benefit.

What this research studies

Researchers will enroll 200 infants at 3 months and monitor their glucose patterns every few months using a CGM device. They will examine whether early exposure to added sugars is linked to greater glucose variability and higher weight gain in the first two years of life. The study uses continuous glucose monitoring data, growth measurements, and dietary information to explore connections between early nutrition, glucose control, and obesity risk. The goal is to understand if early sugar intake sets a metabolic trajectory that increases diabetes risk later. Participation would involve regular visits and wearing a CGM sensor during key ages.

Why it matters

Potential benefit: If successful, it could inform guidelines for infant feeding to reduce future obesity and diabetes risk.

How similar studies have gone: Previous work suggests early sugar exposure affects weight and later sugar intake, but direct links to real-time glucose patterns are being explored in this study.

Where this research is happening

  • Children's Mercy Hosp (Kansas City, Mo)
    Kansas City, United States
    Active

Researchers

  • Principal investigator: Kong, Kai Ling — Children's Mercy Hosp (Kansas City, Mo)
  • Study coordinator: Kong, Kai Ling

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.