NIH-funded research R21 grant

An inhaled medicine for tiny babies' lungs

Official title: Inhaled ciclesonide - a phase I study in preterm infants

Funded at Children's Mercy Hosp (Kansas City, Mo) · NIH-11161516 · Data updated 2026-11-12

This research is exploring a new inhaled medicine called ciclesonide to help protect the lungs of very premature babies.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionChildren's Mercy Hosp (Kansas City, Mo)
NIH-funded
Lab location1 site (Kansas City, United States)
Project startAugust 5, 2024
Project endJuly 31, 2027
Funding year2025
Award (this year)$195,800
NIH project number5R21HD116421-02
Project IDNIH-11161516 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research would be very premature infants born before 30 weeks of gestation.

Less likely to help

Patients who are not premature infants or those without risk of bronchopulmonary dysplasia would not receive direct benefit from this specific research.

What this research studies

Very premature babies often develop a serious lung condition called bronchopulmonary dysplasia (BPD), which can lead to long-term breathing problems. While some medicines are currently used to prevent BPD, they can have serious side effects, including affecting brain development. This project is looking at ciclesonide, an inhaled medicine already approved for asthma in older children, to see if it can protect the lungs of premature infants without these harmful side effects. Researchers have seen promising results in lab studies, suggesting it might be as effective as current treatments but much safer for these vulnerable infants.

Why it matters

Potential benefit: If successful, this medicine could offer a safer way to prevent serious lung disease in premature infants, reducing long-term health problems.

How similar studies have gone: While ciclesonide is approved for asthma in older children, its use for preventing lung injury in premature infants is a novel application, with promising results seen in animal models.

Where this research is happening

  • Children's Mercy Hosp (Kansas City, Mo)
    Kansas City, United States
    Active

Researchers

  • Principal investigator: Sampath, Venkatesh — Children's Mercy Hosp (Kansas City, Mo)
  • Study coordinator: Sampath, Venkatesh

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.