Investigating the immune environment of ovarian cancer tumors to improve survival predictions for patients
Spatial and Bayesian modeling methods for assessment of the tumor immune microenvironment and survival of women with ovarian cancer
This study is looking at how immune cells behave in ovarian cancer tumors to help doctors understand how they affect the disease and improve treatment options for women with ovarian cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Mercy Hosp (Kansas City, Mo) NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-11083119 on NIH RePORTER |
What this research studies
This research focuses on analyzing the tumor immune microenvironment in women with ovarian cancer using advanced imaging techniques and statistical models. By employing multiplex immunofluorescence microscopy and automated image analysis, the study aims to uncover the spatial distribution of immune cells within tumors, which is crucial for understanding their role in cancer progression. The researchers will develop new statistical methods to analyze this data and create an immunoscore that can predict patient survival outcomes. The study will utilize data from approximately 2,500 ovarian cancer patients to validate these findings and improve treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with epithelial ovarian cancer who are seeking advanced treatment options.
Not a fit: Patients with non-epithelial ovarian cancer or those who are not currently undergoing treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate survival predictions and personalized treatment options for women with ovarian cancer.
How similar studies have performed: Previous research has shown promise in using similar imaging and statistical approaches to analyze tumor microenvironments, indicating potential for success in this novel application.
Where this research is happening
Kansas City, United States
- Children's Mercy Hosp (Kansas City, Mo) — Kansas City, United States (Active)
Researchers
- Principal investigator: Fridley, Brooke L — Children's Mercy Hosp (Kansas City, Mo)
- Study coordinator: Fridley, Brooke L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.