Prevent IgM MGUS from progressing by targeting the driver mutation
Official title: Prevent IgM MGUS Progression by Targeting the Driver Mutation
Funded at Children's Mercy Hosp (Kansas City, Mo) · NIH-11396414 · Data updated 2026-11-12
A patient-facing program aims to stop progression of IgM MGUS to serious blood cancers by attacking a key cancer-causing mutation with AI-guided drug discovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Mercy Hosp (Kansas City, Mo) NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $130,859 |
| NIH project number | 7U54CA272691-04 |
| Project ID | NIH-11396414 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with IgM MGUS who are at risk of progression to WM, NHL, CLL, or AL amyloidosis.
✕Less likely to help
Patients without IgM MGUS or without progression risk may not benefit from this research.
What this research studies
This project focuses on people with IgM MGUS, a condition that raises the risk of certain blood cancers. Researchers are using artificial intelligence to screen millions of compounds to find ones that block the harmful MYD88 L265P mutation that drives cancer in many patients. The work combines AI technology with laboratory studies to identify potential preventive treatments. If successful, this could lead to new strategies to prevent progression and improve long-term health for affected individuals.
Why it matters
Potential benefit: If successful, patients with IgM MGUS could gain new preventive options to reduce cancer risk.
How similar studies have gone: Similar AI-guided drug discovery approaches are showing promise in identifying targeted compounds, though this exact mutation-directed strategy is being explored.
Where this research is happening
-
Children's Mercy Hosp (Kansas City, Mo)
Kansas City, United States Active
Researchers
- Principal investigator: Li, Yong — Children's Mercy Hosp (Kansas City, Mo)
- Study coordinator: Li, Yong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.