Understanding genetic causes of pregnancy loss
5-base HiFi sequencing to advance the understanding of genetic determinants of pregnancy loss
This study is looking at the genetic reasons behind unexplained pregnancy losses by examining DNA from both parents and the babies that didn't make it, and it's designed for families who have experienced recurrent pregnancy loss to help us learn more about what might be causing it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Mercy Hosp (Kansas City, Mo) NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-11141044 on NIH RePORTER |
What this research studies
This research aims to uncover the genetic factors that contribute to unexplained recurrent pregnancy loss (RPL) by analyzing DNA from both parents and fetal cells from pregnancy losses. The study will utilize advanced sequencing technology to identify genetic variants and methylation patterns that may play a role in RPL. By integrating clinical data and electronic health records, the research seeks to provide a comprehensive understanding of the genetic landscape associated with pregnancy loss. Families with a history of RPL will be involved to help gather detailed genetic information.
Who could benefit from this research
Good fit: Ideal candidates for participation include families with a history of unexplained recurrent pregnancy loss, particularly those with children aged 0-11.
Not a fit: Patients who have not experienced recurrent pregnancy loss or those without a genetic component to their pregnancy issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved genetic testing and personalized care for families experiencing recurrent pregnancy loss.
How similar studies have performed: Previous research has shown promise in using advanced genomic techniques to identify genetic causes of pregnancy loss, indicating that this approach may yield valuable insights.
Where this research is happening
Kansas City, United States
- Children's Mercy Hosp (Kansas City, Mo) — Kansas City, United States (Active)
Researchers
- Principal investigator: Grundberg, Elin — Children's Mercy Hosp (Kansas City, Mo)
- Study coordinator: Grundberg, Elin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.