Cancer prevention against MGUS progression
Official title: Cancer Prevention-Interception Against MGUS Progression
Funded at Children's Mercy Hosp (Kansas City, Mo) · NIH-11396398 · Data updated 2026-11-12
A nationwide center is being created to stop MGUS from turning into blood cancers by identifying targets and using precision prevention strategies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Mercy Hosp (Kansas City, Mo) NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,170,519 |
| NIH project number | 7U54CA272691-04 |
| Project ID | NIH-11396398 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with MGUS, a condition that raises cancer risk, who are eligible for prevention-focused research and potential future interventions.
✕Less likely to help
MGUS patients with very low risk or those not enrolled in prevention studies may not receive direct benefits.
What this research studies
This project aims to build a specialized center that connects researchers and clinics to prevent MGUS from becoming cancer. It will study the immune system and bone marrow environment to find the molecules and conditions that drive progression. The center will develop and test prevention approaches that could keep MGUS patients from developing multiple myeloma or related diseases. It emphasizes collaboration, agile research, and translation so findings can reach patients sooner.
Why it matters
Potential benefit: If successful, MGUS patients could avoid progression to deadly blood cancers through targeted prevention strategies.
How similar studies have gone: Similar cancer-prevention and interception concepts have progressed in other high-risk conditions, but CAP-MGUS explores a focused MGUS-specific approach.
Where this research is happening
-
Children's Mercy Hosp (Kansas City, Mo)
Kansas City, United States Active
Researchers
- Principal investigator: Li, Yong — Children's Mercy Hosp (Kansas City, Mo)
- Study coordinator: Li, Yong
Related research
Other NIH-funded projects on the same topics.
-
Optimal dosing of brain drugs for children
This project aims to figure out the best doses for medicines that affect the brain in kids, by studying how much drug reaches the brain and using non-invasive ways to measure it.
-
Chronic Kidney Disease in Children: following young people as they grow up with CKD
A long-term study in kids with chronic kidney disease tracks kidney function and heart health as they transition into adulthood.
-
Chronic Kidney Disease in Children follow-up study
A long-term study that follows kids with kidney disease as they grow into young adults, collecting health data from home and official records.
-
CKiD Cardiovascular Testing Travel Supplement
A funding opportunity to help adolescents and young adults with CKD travel to sites where important heart and blood-vessel tests can be done, with a parent accompanying them.
-
Unraveling genetic causes of unsolved pediatric leukodystrophy with HiFi long-read sequencing
A pediatric-focused study tests how advanced long-read genome sequencing can find hidden genetic causes in kids with leukodystrophy who were not diagnosed using standard tests.
-
Early sugar exposure in infancy and how it affects glucose and obesity risk
This project follows babies from age 3 months to 12 months to see if higher added sugars in formula and early foods lead to more variable blood sugar and faster weight gain.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.