Condition

Trigeminal Neuralgia clinical trials and research

• 17Clinical trials
• 1NIH research projects
• 10Countries

Newest Trigeminal Neuralgia clinical trials

All recruiting trials (17)

• RP-008 with daily varenicline for trigeminal neuralgia

  A new treatment approach tests RP-008 together with varenicline to see if it is safe, tolerable, and offers pain relief for adults with trigeminal neuralgia.

  Recruiting Phase 1/2 Kriya Therapeutics, Inc. · Sherbrooke · NCT07596485

• Using intravenous lacosamide to treat acute pain in trigeminal neuralgia

  This study is testing if intravenous lacosamide can help relieve severe facial pain in people with trigeminal neuralgia who come to the emergency room.

  Recruiting Hospital Universitari de Bellvitge · L'Hospitalet de Llobregat, Barcelona · NCT06851910

• Comparing two types of radiofrequency treatments for trigeminal neuralgia pain

  This study is testing which type of radiofrequency treatment, bipolar or monopolar, works better for relieving pain in people with trigeminal neuralgia who haven't found relief from other medications.

  Recruiting at 2 sites Alexandria University · Alexandria and 1 other locations · NCT06779578

• Evaluating outcomes in neurosurgery using standardized measures

  This study is trying to see how different factors affect the results of brain surgeries by collecting information from patients before and after their operations.

  Recruiting at 11 sites Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Bergamo, BG and 26 other locations · NCT06724029

• Comparing two methods for treating facial pain from trigeminal neuralgia

  This study is testing whether a new combination of treatments for facial pain from trigeminal neuralgia works better than a single treatment to help adults feel less pain and improve their daily life.

  Recruiting Zagazig University · Zagazig, Sharqia Province · NCT06684275

• Exploring the link between emotion, memory, and chronic facial pain

  This study is trying to see how chronic facial pain affects memory and emotions by looking at brain changes in people with trigeminal neuralgia.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06518421

• Evaluating Peripheral Nerve Stimulation for Postherpetic Neuralgia

  This study is testing if a new nerve stimulation treatment can help people with postherpetic neuralgia manage their pain better.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT06290661

• Evaluating masseter muscle thickness after nerve treatment for trigeminal neuralgia

  This study is testing whether a specific nerve treatment for trigeminal neuralgia can change the thickness of the masseter muscle in patients who haven't found relief from other medications.

  Recruiting Başakşehir Çam & Sakura City Hospital · Istanbul, Başakşehir · NCT06278194

• Using Botox to treat Trigeminal Neuralgia

  This study is testing if Botox can help people with trigeminal neuralgia who haven't found relief from other treatments by seeing if it reduces their pain attacks.

  Recruiting Phase 4 Stanford University · Stanford, California · NCT06216886

• Using trigeminal evoked responses to enhance rhizotomy for facial pain relief

  This study is testing if measuring brain responses during surgery can help improve pain relief for adults with trigeminal neuralgia who are having rhizotomy.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT05738096

• Evaluating radiosurgery for treating trigeminal neuralgia

  This study is testing if a special type of radiation treatment can help relieve pain for people with trigeminal neuralgia.

  Recruiting Centre Hospitalier Princesse Grace · Monaco · NCT05677243

• Deep brain stimulation for severe facial pain caused by a pontine lesion

  This study is testing if deep brain stimulation can help people with severe facial pain from a pontine lesion, especially those who haven't found relief from other treatments.

  Recruiting Phase 1 Université de Sherbrooke · Sherbrooke, Quebec · NCT05451251

• Measuring nerve responses during facial pain treatment

  This study is testing how nerve responses change in people with trigeminal neuralgia before and after a specific pain treatment to better understand the effects of the procedure.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT05269472

• Using stem cell exosomes to treat Trigeminal Neuralgia

  This study is testing if a treatment using stem cell exosomes can help people with Trigeminal Neuralgia feel better and reduce their pain.

  Recruiting at 2 sites Phase 1 The Foundation for Orthopaedics and Regenerative Medicine · Naples, Florida and 1 other locations · NCT05152368

• Assessing Trigeminal Neuralgia with Advanced MRI Techniques

  This study is testing advanced MRI techniques to see if they can help doctors understand the causes of trigeminal neuralgia better and improve treatment options for patients.

  Recruiting Fondation Ophtalmologique Adolphe de Rothschild · Paris · NCT05051072

• Observational study on cluster headaches and trigeminal neuralgia

  This study is trying to learn more about cluster headaches and trigeminal neuralgia by gathering information from patients to help match them for future treatments.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT02910323

• Long-term tracking of Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy use

  This study is tracking how well Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy work for treating tumors over time to help improve patient care.

  Recruiting at 2 sites The Radiosurgery Society · Colorado Springs, Colorado and 12 other locations · NCT01885299

NIH-funded research (1)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• SN102: a gene therapy idea to ease trigeminal neuralgia pain

  A new gene therapy approach aims to durably ease trigeminal neuralgia pain with a one-time treatment delivered locally to peripheral nerves.

  NIH research Sereneuro Therapeutics, INC. · Baltimore, United States · NIH-11312165

Related topics

Quick answers

How many Trigeminal Neuralgia clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in United States (6 trials), Canada (3 trials), Egypt (2 trials), Monaco (1 trial), Turkey (Türkiye) (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 1/2: 1, Phase 4: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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