Evaluating Peripheral Nerve Stimulation for Postherpetic Neuralgia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to assess the safety and efficacy of percutaneous peripheral nerve stimulation in patients suffering from postherpetic neuralgia. Participants will undergo the implantation of a nerve stimulation electrode and will be randomly assigned to either an active stimulation group or a placebo group based on their pain reduction. The study will involve a baseline assessment, followed by a treatment period where stimulation parameters will be adjusted, and a follow-up period where participants will track their pain levels and medication use. The trial is conducted across four clinical sites in China, enrolling a total of 56 subjects.

Why it matters

Who can join: the full rules

Inclusion criteria:

* 18 years old and above, male or female
* Diagnosed by trained clinical doctors as postherpetic neuralgia, which is an indication for peripheral nerve stimulation therapy;
* Assess the damage or disease of the peripheral sensory system through the four questions of Douleur Neuropathy before surgery;
* The subject has received conventional treatment but the efficacy is poor, or cannot tolerate the side effects of conventional treatment;
* Visual analogue scale for pain within 24 hours before surgery ≥ 5;
* The subjects are able to understand the purpose of this study, have sufficient compliance with the research treatment, and are willing to sign an informed consent form;

Exclusion criteria:

* Subjects who need to receive both radio frequency modulation and intrathecal drug infusion treatment simultaneously;
* Subjects who are known to have cardiac implants (pacemakers or defibrillators) or other implantable neural stimulators (spinal cord stimulators or deep brain stimulators, etc.);
* Subjects with severe psychological and/or mental disorders and/or non therapeutic drug dependence;
* Subjects expected to undergo MRI examination within 30 days after PNS implantation;
* Expected to be discharged within 48 hours or less;
* Target nerve damage or muscle defects in known pain areas;
* Subjects who are known to be allergic to skin contact materials (tape or adhesive);
* Allergy to anesthetics such as lidocaine;
* Concomitant severe heart disease, liver disease, kidney disease, respiratory system disease, and coagulation dysfunction;
* Pregnant women, lactating women, or women planning to have children within the next three months;
* Subjects who have participated in any other clinical trial, or who may participate in any other trial after enrollment;
* Other situations that the researcher deems unsuitable for participation in this clinical trial

Where it's running

• Union Hospital, Tongji medical college, Huazhong University of Science and Technology
  Wuhan, Hubei, China Recruiting

Study contacts

• Study coordinator: Dong Yang, PHD
• Email: dongyang118@sina.com
• Phone: 13871230491

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• RP-008 with daily varenicline for trigeminal neuralgia

  A new treatment approach tests RP-008 together with varenicline to see if it is safe, tolerable, and offers pain relief for adults with trigeminal neuralgia.

  Recruiting Phase 1/2 Kriya Therapeutics, Inc. · Sherbrooke · NCT07596485

• Erector spinae plane block versus transcutaneous radiofrequency for postherpetic neuralgia

  This project will see if erector spinae plane block or transcutaneous radiofrequency works better to reduce pain in adults with postherpetic neuralgia.

  Recruiting Diskapi Teaching and Research Hospital · Ankara · NCT07400640

• Transcutaneous pulsed radiofrequency for postherpetic neuralgia pain

  This study will try a non-invasive pulsed radiofrequency treatment applied through the skin to reduce pain in adults with postherpetic neuralgia who have not responded to standard treatments.

  Recruiting Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization · Istanbul, Istanbul · NCT07390279

• Venlafaxine to prevent postherpetic neuralgia after shingles

  This study will test whether giving venlafaxine to adults with recent shingles reduces the chance of developing postherpetic neuralgia.

  Recruiting Beijing Tiantan Hospital · Beijing · NCT07361796

• Y-4 for postherpetic neuralgia

  This will test whether Y-4 reduces nerve pain in adults with postherpetic neuralgia compared with pregabalin.

  Recruiting Phase 2 Neurodawn Pharmaceutical Co., Ltd. · Nanjing, Jiangsu · NCT07275762

• VMD-3866 topical gel for chemotherapy-induced nerve pain

  This trial will test whether a non-opioid topical gel called VMD-3866 can reduce pain in adults with chemotherapy-induced peripheral neuropathy.

  Recruiting Phase 2 VM Therapeutics LLC · London, UK · NCT07072468

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.