Using Botox to treat Trigeminal Neuralgia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of onabotulinumtoxin A (Botox) for patients suffering from trigeminal neuralgia who have not found relief from medications and are not candidates for surgery. Participants will receive injections of Botox or a saline placebo in the area of pain, and their response will be monitored over a three-month period. The goal is to determine if Botox can significantly reduce the frequency of pain attacks in these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Men and women age 18 or older

* Judged to be of legal competence
* Sufficient knowledge of written and spoken English
* Capable of attending regular in-person visits
* Have failed/not a candidate/do not want surgery
* Inadequate response to medication - at least 2 trials
* Meeting ICHD criteria for Classical Trigeminal Neuralgia 13.1.1.1
* Patients with frequency \> 10 attacks per week
* Stable dose of medications in the last 2 weeks

Exclusion Criteria:

* Secondary or Idiopathic TN, or Painful Trigeminal Neuropathy as defined by the ICHD (13.1.1.2, 13.1.1.3, 13.1.2)
* Pregnant or breast feeding (while it is rare that a patient will be pregnant with TN, there is not sufficient data to say definitively that onabotA is ok to use during pregnancy and nursing, it is still rated Class C)
* Neuromuscular disease
* On aminoglyocosides
* Not currently enrolled in any other studies

Where it's running

• Meredith Barad
  Stanford, California, United States Recruiting

Study contacts

• Principal investigator: Meredith Barad, MD — Stanford University
• Study coordinator: Meredith Barad, MD
• Email: nlariyos@stanford.edu
• Phone: 6507217218

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Comparing two types of radiofrequency treatments for trigeminal neuralgia pain

  This study is testing which type of radiofrequency treatment, bipolar or monopolar, works better for relieving pain in people with trigeminal neuralgia who haven't found relief from other medications.

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  Recruiting at 11 sites Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Bergamo, BG and 26 other locations · NCT06724029

• Comparing two methods for treating facial pain from trigeminal neuralgia

  This study is testing whether a new combination of treatments for facial pain from trigeminal neuralgia works better than a single treatment to help adults feel less pain and improve their daily life.

  Recruiting Zagazig University · Zagazig, Sharqia Province · NCT06684275

• Exploring the link between emotion, memory, and chronic facial pain

  This study is trying to see how chronic facial pain affects memory and emotions by looking at brain changes in people with trigeminal neuralgia.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06518421

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.