Observational study on cluster headaches and trigeminal neuralgia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Will Erwin Headache Research Center is creating a national registry for patients with Cluster Headache and Trigeminal Neuralgia. This observational study will categorize participants based on various characteristics such as type and severity of their condition, associated symptoms, and psychological factors. Detailed evaluations will include genomic studies, medical history, imaging reports, and physical exams. The goal is to better understand these conditions and facilitate patient matching for future interventional clinical trials.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of a trigeminal autonomic cephalalgia according to the International Headache Classification including episodic cluster headache, chronic cluster headache, episodic paroxysmal hemicrania, chronic paroxysmal hemicrania, episodic short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT), chronic SUNCT, episodic short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA), chronic SUNA, and hemicrania continua. OR Diagnosis of a trigeminal neuralgia according to the International Headache Classification, including classical trigeminal neuralgia and symptomatic trigeminal neuralgia.
* Able to provide HIPAA authorization to share prior medical records/imaging.

Exclusion Criteria:

* Life expectancy less than 1 year, co-existing disease or other characteristic that precludes appropriate diagnosis of a trigeminal autonomic cephalalgia or trigeminal neuralgia.
* Active drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements
* Inability or unwillingness of subject or legal guardian/representative to give informed consent.

Inclusion Criteria for Healthy Volunteers:

* Inclusion criteria is willingness to consent and be of age 18 and older

Where it's running

• The University of Texas Health Science Center at Houston
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Mark Burish, MD, PhD — The University of Texas Health Science Center, Houston
• Study coordinator: Rebecca Martinez, RN
• Email: nctt.wec@uth.tmc.edu
• Phone: 713-486-7771

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• RP-008 with daily varenicline for trigeminal neuralgia

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• Yoga-based Movements for Primary Headaches (YOURHEAD)

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• Using intravenous lacosamide to treat acute pain in trigeminal neuralgia

  This study is testing if intravenous lacosamide can help relieve severe facial pain in people with trigeminal neuralgia who come to the emergency room.

  Recruiting Hospital Universitari de Bellvitge · L'Hospitalet de Llobregat, Barcelona · NCT06851910

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.