Using intravenous lacosamide to treat acute pain in trigeminal neuralgia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the effectiveness and safety of intravenous lacosamide as a rescue treatment for acute pain in patients with trigeminal neuralgia presenting to the emergency department. Conducted at Hospital Universitari de Bellvitge, the study will enroll approximately 20 patients over two years, assessing pain response using a Numerical Pain Rating Scale at various time points. The study aims to provide insights into the potential benefits of lacosamide for patients experiencing severe facial pain that is resistant to conventional therapies.

Why it matters

Who can join: the full rules

All patients diagnosed with trigeminal neuralgia who present to the emergency department of Hospital de Bellvitge for an acute pain exacerbation and are prescribed intravenous lacosamide as symptomatic pain treatment, according to the treating physician's discretion, will be considered for inclusion.

Inclusion Criteria:

* Diagnosis of classical or idiopathic trigeminal neuralgia according to the criteria of the International Classification of Headache Disorders (ICHD-3).
* Age over 18 years.
* Signed informed consent.

Exclusion Criteria:

* Contraindication for treatment with lacosamide (previous hypersensitivity reaction, known atrioventricular block).
* Mental or psychiatric illness that interferes with the ability to understand and sign the informed consent.
* Language barrier.
* Lack of cooperation.

Where it's running

• Hospital de Bellvitge
  L'Hospitalet de Llobregat, Barcelona, Spain Recruiting

Study contacts

• Principal investigator: Albert Muñoz Vendrell, PhD — Hospital Universitari de Bellvitge

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• RP-008 with daily varenicline for trigeminal neuralgia

  A new treatment approach tests RP-008 together with varenicline to see if it is safe, tolerable, and offers pain relief for adults with trigeminal neuralgia.

  Recruiting Phase 1/2 Kriya Therapeutics, Inc. · Sherbrooke · NCT07596485

• Comparing two types of radiofrequency treatments for trigeminal neuralgia pain

  This study is testing which type of radiofrequency treatment, bipolar or monopolar, works better for relieving pain in people with trigeminal neuralgia who haven't found relief from other medications.

  Recruiting at 2 sites Alexandria University · Alexandria and 1 other locations · NCT06779578

• Evaluating outcomes in neurosurgery using standardized measures

  This study is trying to see how different factors affect the results of brain surgeries by collecting information from patients before and after their operations.

  Recruiting at 11 sites Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta · Bergamo, BG and 26 other locations · NCT06724029

• Comparing two methods for treating facial pain from trigeminal neuralgia

  This study is testing whether a new combination of treatments for facial pain from trigeminal neuralgia works better than a single treatment to help adults feel less pain and improve their daily life.

  Recruiting Zagazig University · Zagazig, Sharqia Province · NCT06684275

• Exploring the link between emotion, memory, and chronic facial pain

  This study is trying to see how chronic facial pain affects memory and emotions by looking at brain changes in people with trigeminal neuralgia.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT06518421

• Evaluating Peripheral Nerve Stimulation for Postherpetic Neuralgia

  This study is testing if a new nerve stimulation treatment can help people with postherpetic neuralgia manage their pain better.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT06290661

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.